Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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Metabolic Abnormalities in Idiopathic Parkinson's Diseases with Unilateral Symptoms

  • Choe, Bo-Young (Departments of Biomedical Engineering, Neurosurgery, The Catholic University of Korea) ;
  • Kim, Moon-Chan (Departments of Biomedical Engineering, Radiology, The Catholic University of Korea) ;
  • Kim, Bum-Soo (Departments of Biomedical Engineering, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jae-Moon (Departments of Biomedical Engineering, College of Medicine, The Catholic University of Korea)
  • Published : 2004.06.01
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Abstract

Authors investigated whether there is a lateral effect of $^1$H MRS observable metabolite ratios between the symptomatic and the nonsymptomatic side in the early stage of Parkinson's disease with unilateral symptom. Localized in vivo $^1$H MR spectroscopy (MRS) was used to measure the metabolite levels in the symptomatic and the nonsymptomatic sides of the lentiform nucleus in Parkinson"s disease with unilateral symptom (N=25). The metabolite ratios of NAA/Cr and Cho/Cr in the symptomatic side were compared with those in the nonsymptomatic side. Significant metabolic lateral effect of NAA/(Cho+Cr) ratio was established between the symptomatic and the nonsymptomatic side of lentiform nucleus in Parkinson's disease with unilateral symptom (p<0.05). The ratio of NAA/(Cho+Cr) homolateral to the sympatomatic side of the patient is also lower than that of the control (P<0.05). On the basis of NAA/Cr ratios of lentiform nucleus between the symptomatic and the nonsymptomatic side, the present $^1$H MRS study shows a significant neuronal laterality in Parkinson's disease with unilateral symptom. In vivo $^1$H MRS may provide a diagnostic marker for neuronal dysfunction in Parkinson's disease with unilateral symptom.

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