YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antioxidative Activity and Protection of Oxidative Chromosomal Damage by Vegetables, Fruits Extract and Their Functional Liquid Formulation

야채 및 과일추출물의 항산화작용과 산화적 염색체손상에 대한 억제효과

  • 이승철 (강원대학교 약학대학) ;
  • 허찬 (강원대학교 약학대학) ;
  • 이승현 (강원대학교 약학대학) ;
  • 김현표 (강원대학교 약학대학) ;
  • 허문영 (강원대학교 약학대학)
  • Published : 2004.04.01
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Abstract

The ethanol extracts of mixed vegetables (Bioactive Vegetables, BV), mixed fruits (Bioactive Fruits, BF) and their liquid formulation (Chungpae Plus , CP) were evaluated for their antioxidative and antigenotoxic activities. They were shown to possess the significant free radical scavenging effect against 1,1-diphenyl-2-picryl hydrazine (DPPH) radical generation and were revealed to show the inhibitory effect of lipid peroxidation as measured by malondialdehyde (MDA) formation although the potencies were not higher than those of vitamin C. They did not possess any pro-oxidant effect on bleomycin-Fe(III) dependent DNA degradation, whereas vitamin C showed strong pro-oxidant effect. Furthermore, oral administration of BV and BF inhibited micronucleated reticulocyte (MNRET) formation of mouse peripheral blood induced by KBrO3 treatment in vivo. CP also showed significant inhibition under same experimental condition. Therefore, the liquid formulation (CP) containing BV and BF may be a useful natural antioxidative and antigenotoxic agent by scavenging free radicals, inhibition of lipid peroxidation and protecting chromosomal damage.

Keywords

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