Journal of Korean Academy of Nursing (대한간호학회지)

Korean Society of Nursing Science (한국간호과학회)
권호 표지

Effect of DHEA on Hindlimb Muscles in a Focal Cerebral Ischemia Model Rat

DHEA 투여가 국소 뇌허혈 모형 쥐의 하지근에 미치는 효과

  • 안경주 (대구가톨릭대학교 의과대학 간호학과)
  • Published : 2004.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: The purpose of this study was to determine the effect of DHEA on hindlimb muscles(soleus, plantaris and gastrocnemius) in a focal brain ischemia model rat. Method: Twenty-seven male Sprague-Dawley rats were randomly divided into three groups: CINS(cerebral ischemia + normal saline), CIDH(cerebral ischemia + DHEA), or SHNS(sham + normal saline). Both the CINS and CIDH groups underwent a transient right middle cerebral artery occlusion operation. In the SHNS group, a sham operation was done. 0.34mmol/kg DHEA was administered daily by an intraperitoneal injection for 7days. Results: The muscle weight, muscle fiber cross-sectional area of the Type I muscle fiber of soleus and Type II muscle fiber of plantaris and gastrocnemius, myofibrillar protein content of gastrocnemius, and muscle strength in the CINS group decreased compared with the SHNS group. The muscle weight, muscle fiber cross-sectional area of the Type II muscle fiber of plantaris and gastrocnemius, myofibrillar protein content of soleus, and muscle strength in the CIDH group increased compared with the CINS group. Conclusion: It was identified that muscle atrophy could be induced during 7 days after a cerebral infarction, and DHEA administration during the early stages of a cerebral infarction might attenuate muscle atrophy.

Keywords

References

  1. An, G. J., Lee, Y. K., Im, J. H., Choi, S. M., & Choe, M. A. (2000). Effect of endurance exercise on hindlime muscle mass of acute stroke rat. J Korean Biol Nurs Sci, 2(2),67-80
  2. Choe, M. A., Hong, H. S., Park, M. J., Choi, S. M., Lee, K. S., Seo, H. S., & Shin, G. S. (2001). Pathophysiology. Seoul: Kyechuk Co
  3. Cho, S. C., Choi, K. H., Lee, D. J., & Ha, S. B. (1998). Interval between initial hospital arrival and start of rehabilitation therapy in stroke patients of tertiary medical center. J Korean Acad Rehab Med, 22(1), 9-14
  4. Bezkorovainy, A., & Rafelson, M. E. (1995). Concise Biochemistry. New York: Maecel Dekker. 546-548
  5. Bourbonnais, D., & Noven, S. V. (1989). Weakness in patients with hemiparesis. Am J Occup Therapy, 313-319
  6. Brown, G. A., Vukovich, M. D., Sharp, R. L., Reifenrath, T. A., Parsons, K. A., & King, D. S. (1999). Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl Physiol, 87(6), 2274-2283
  7. Dattola, R., Girlanda, P., Vita, G., Santoro, M., Roberto, M. L., Toscano, A., Venuto, C., Baradello, A., & Messina, C. (1993). Muscle rearrangement in patients with hemiparesis after stroke: an electrophysiological and morphological study. Eur Neurol, 33(2), 109-114
  8. Davalos, A., Ricart, W., Gonzalez, F., Soler, S., Marrugat, J., Molins, A., Suner, R., & Genis, D. (1996). Effect of malnutrition after acute stroke on clinical outcome. Stroke,27(6), 1028-1032
  9. Dennis, M. (2000). Nutrition after stroke. Br Med Bull, 56(2), 466-475
  10. Goldfarb, A. H., Mcintosh, M. K., Boyer, B. T., & Fatouros, J. (1994). Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rat. J Appl Physiol, 76(4), 1630-1635
  11. Griggs, R. C., Kingston, W., Josefowicz, R. F., Herr, B. F., Forbes, G., & Haliday, D. (1989). Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol, 66, 498-503
  12. Haddad, F., Arnold, C., Zeng, M., & Baldwin, K. (1997). Interaction of thyroid state and denervation on skeletal myosin heavy chain expression. Muscle & Nerve, 20, 1487-1496 https://doi.org/10.1002/(SICI)1097-4598(199712)20:12<1487::AID-MUS2>3.0.CO;2-4
  13. Holecek, M. (2001). Effect of starvation on branched- chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle. Physiol Res, 50(1), 19-24
  14. Hornsby, P. (1997). DHEA: A biologist's perspective. J Am Geriatr Soc, 45(11), 1395-1401
  15. Jorgensen, L., & Jacobson, B. K. (2001). Changes in muscle mass, fat mass, and bone mineral content in the legs after stroke: a Iyear prospective study. Bone, 28(6), 655-659
  16. Kenji, H., Yuichi, U., & Hajime, a. (1997). Disuse muscle atrophy of lower limbs in hemiplegic patients. Archa Physical Med Rehab, 78, 13-18 https://doi.org/10.1016/S0003-9993(97)90003-4
  17. KWak, C. S., Kang, C. M., Kang, H. S., Song, K. Y., Lee, M. S., Song, S. C., & Park, S. C. (2000). Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model. J Korean Med Sci, 15, 533-541
  18. Loughna, P., Goldspink, G., & Goldspink, D. F. (1986). Effect of inactivity and passive stretch on protein turnover in phasic and postural rat muscles. J Appl Physiol, 61(1), 173-179
  19. Martini, F. H., Ober, W. C., Garrison, C. W., Welch, K., & Hutchings, R. T. (2001). Fundamentals of Anatomy & Physiology. New Jersey: Prentice Hall
  20. McArdle, W. D., Katch, F. I., & Katch, V. L. (1996). 158 Exercise physiology. Baltimore: Wiliams & Wilkins
  21. Millward, D. J., Garlick, P. J., Stewart, R. J., Nnanyelugo, D.a., & Waterlow, J. C. (1975). Skeletal muscle growth and protein turnover. J Biochemistry, 150, 235-243
  22. Morales, A. J., Haubrich, R .H., Hwang, J. Y., Asakura, & Yen, S. S. C. (1998). The effect of six months treatment with a 100mg daily dose of DHEA on circulationg sex steroids, body composition and muscle strength in age-advanced men and women. J Clin Endocrinol Metab, 78, 1360-1367 https://doi.org/10.1210/jc.78.6.1360
  23. Nagasawa, H., & Kogure, K. (1989) Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke, 20, 1037-043
  24. Nestler, J. E., Barlascini, C. D., Clore, J. N., & Blackard, W. G. (1988). DHEA reduces serum low lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab, 66, 57
  25. Robinzon, B., & Cutolo, M. (1999). Should dehydroepiandrosterone replacement therapy be provided with glucocorticoids?, Rheumatology, 38(6), 488-495 https://doi.org/10.1093/rheumatology/38.6.488
  26. Scelsi, R., Lotta, G., Lammi, P., & Marchetti, C. (1984). Hemiplegic atrophy. Acta Neuropathol(Berl), 62, 324-331 https://doi.org/10.1007/BF00687615
  27. Shin, J. C., Yoon, T. S., Chun,S. I., Kim, M. Y., & Yim, K. B. (1994). Strength of elbow flexors and extensors in normal and hemiplegic subjects. J Korean Acad Rehab Med, 18(1), 20-27
  28. Tagliaferro, A. R., Davis, J. R., Truchon, S., & Hamont, N.(1986). Effects of DHEA on metabolism, body weight and composition of male and female rats. J Nutr, 116,1977-1983
  29. Taylor, J. A. & Kandarian, S. C. (1994). Advantage of normalizing force production to myofibrillar protein in skeletal muscle cross-sectional area. J Appl Physiol, 76(2), 974-978
  30. Yonemori, F., Yamaguchi, T., Yamada, H., & Tamura, A. (1998). Evaluation of motor deficit after chronic focal ischemia in rats. J Cerebr Blood Flow Metab, 18( 10), 1099-1106