Archives of Pharmacal Research

  • 제27권7호
  • /
  • Pages.790-796
  • /
  • 2004
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Wild Ginseng Prevents the Onset of High-Fat Diet Induced Hyperglycemia and Obesity in ICR Mice

  • Yun, Se-Na (Laboratory of Pharmacology and Clinical Pharmacy, School of Pharmacy, Kyung Hee University) ;
  • Moon, Sang-Jung (Sansam Nara Corp.) ;
  • Ko, Sung-Kwon (Korea Ginseng Institute, Chung-Ang University) ;
  • Im, Byung-Ok (Korea Ginseng Institute, Chung-Ang University) ;
  • Chung, Sung-Hyun (Laboratory of Pharmacology and Clinical Pharmacy, School of Pharmacy, Kyung Hee University)
  • 발행 : 2004.07.01
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초록

Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as 1920s. Although wild ginseng was anecdotally thought to be superior to cultivated ginseng as far as pharmacological properties were concerned, there have been no prior reports on the antidiabetic effect of wild ginseng. In this study, we investigated the preventative anti-diabetic and anti-obese effects of wild ginseng ethanol extract (WGEE). In the preventive experiment, WGEE co-administered with a high fat diet significantly inhibited body weight gain, fasting blood glucose, triglyceride, and free fatty acid levels in a dose dependent manner. WGEE-treated mice at doses of 250 and 500 mg/kg improved the insulin resistance index by 55％ and 61％ compared to the high fat diet (HFD) control, respectively. Diameters of white and brown adipocytes were also decreased by 62％ and 46％ in the WG500-treated group compared to those in HFD fed control mice. Taken together, WGEE has potential as a preventive agent for type 2 diabetes mellitus (and possibly obesity) and deserves clinical trial in the near future.

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참고문헌

  1. Assinewe, V. A., Baum, B. R., Gagnon, D., and Amason, J. T., Phytochemistry of Wild Populations of Panax quinquefolius L. (North American Ginseng). J. Agric. Food. Chem., 51, 4549-4553 (2003) https://doi.org/10.1021/jf030042h
  2. Attele, A. S., Wu, J. A., and Yuan, C. S., Multiple pharma-cological effects of ginseng. Biochem. Pharmacol., 58, 1685-1693 (1999) https://doi.org/10.1016/S0006-2952(99)00212-9
  3. Attele, A. S., Zhou, Y. P., Xie, J. T., Wu, J. A., Zhang, L., and Dey, L., Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes, 51, 1851-1858 (2002) https://doi.org/10.2337/diabetes.51.6.1851
  4. Cavaghan, M. A, Ehrmann, D. A., and Polonsky, K. S., Interaction between insulin resistance and insulin secretion in the development of glucose intolerance. J. Clin. Invest., 106, 329-333 (2000) https://doi.org/10.1172/JCI10761
  5. Chevallier, A., Encyclopedia of herbal medicine. New York: DK Publishing (2000)
  6. Chung, S. H., Choi, C. G., and Park, S. H., Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch. Pharm. Res., 24, 214-218 (2001) https://doi.org/10.1007/BF02978260
  7. Cousin, B., Agou, K., Leturque, A, Ferre, P., Girard, J., and Penicaud, L., Molecular and metabolic changes in white adipose tissue of the rat during development of ventromedial hypothalamic obesity. Eur. J. Biochem., 207, 377-382 (1992) https://doi.org/10.1111/j.1432-1033.1992.tb17060.x
  8. Inzucchi, S. E., Oral anihyperglycemic therapy for type 2 diabetes. J. Am. Med. Assoc., 287, 360-372 (2002) https://doi.org/10.1001/jama.287.3.360
  9. Sotaniemi, E. A., Haapakoski, E., and Rautio, A., Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care, 18, 1373-1375 (1995) https://doi.org/10.2337/diacare.18.10.1373
  10. The Diabetes Control and Complication Trial Research'Group, The effect of intensive treatment of diabetes in the development and progression of long term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med., 329, 977-986 (1993) https://doi.org/10.1056/NEJM199309303291401
  11. UK prospective Diabetes Study group (UKPDS). Intensive blood glucose control with sulphonylurias or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 352, 837-853 (1998) https://doi.org/10.1016/S0140-6736(98)07019-6
  12. Vuksan, V., Sievenpiper, J. L., Xu, Z., Wong, E. Y., Jenkins, A. L., and Beljan-Zdrakovic, U., Konjac-mannan and American ginseng: emerging altemative therapies for type 2 diabetes mellitus. J. Am. Coli. Nutr., 20, 3708-3808 (2001)
  13. Wang, B. X., Advances in study of pharmacology of ginseng. Acta. Phar; Sin., 12, 477-486 (1965)