Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Quinone Reductase Inducer from Radish Leaf Cultivated in the Soil Containing Sulfur

유황시비처리가 열무의 Quinone Reductase 유도물질 생성에 미치는 영향

  • Published : 2004.07.01
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Abstract

Young radishes which were grown in the soil containing sulfur increased quinine reductase (QR) activity in Hepa 1clc cells and isothiocyanate-like compound analyzed by HPLC. QR inducing activity was maximum in young radishes grown with 1,818 g/㎥ sulfur and was decreased when the soil was neutralized with lime mortar in order to improve a recovery. These results have suggested that consumption of young radishes, especially grown in the presence of sulfur, would prevent from cancer incidence through inducing detoxification enzymes and could have therapeutic effects for chemoprevention.

본 연구는 열무에서 다른 십자화과 식물에서 발견되는 sulforaphane 유사물질의 분획과 quinone reductase inducing activity를 측정하였고 열무생육시 유황을 첨가해 주면 이러한 활성이 현저히 증가되는 것을 보았다. Sulforaphane 유사물질의 분획은 유황을 토양에 1,818 g/㎥ 첨가시 가장 높았고, 열무의 생산성을 고려하여 토양을 석회로 중화시켰을 때 감소되었다. 유황을 처리하여 키운 열무에 생리활성성분을 가진 유황화합물이 증가되므로 이러한 열무는 생체에 섭취시 detoxification enzyme을 유도하여 암발생을 지연시키거나 낮출 수 있는 chemoprevention의 효율이 기대된다.

Keywords

References

  1. 신약 김일훈
  2. Proc Natl Acad Sci USA v.89 A major inducer of anticarcinogenic protective enzymes from broccolic: isolation and elucidation of structure Zhang Y;Talalay P;Cho CG;Posner GH https://doi.org/10.1073/pnas.89.6.2399
  3. Proc Natl Acad Sci USA v.94 Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Fahey JW;Zhang Y;Talalay P https://doi.org/10.1073/pnas.94.19.10367
  4. Proc Natl Acad Sci USA v.91 Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates Zhang Y;Kensler TW;Cho CG;Posner GH;Talalay P https://doi.org/10.1073/pnas.91.8.3147
  5. Proc Natl Acad Sci USA v.99 Direct evidence that sulfhydryl groups of keapl are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Dinkova Kostova AT;Holtzclaw WD;Cole RN;Itoh K;Wakabayashi N;Katoh Y;Yamamoto M;Talalay P https://doi.org/10.1073/pnas.172398899
  6. Proc Natl Acad Sci USA v.99 Sulforaphane inhibits extracellular, intracellular, and antibioticresistant strains of Helicobacter pyroli and prevents benzopyrene-induced stomach tumors Fahey J.W.;Haristory X.;Dolan P.M.;Kensler T.W.;Scholtus I.;Stehenson K.K.;Talalay P.;Lozniewski A. https://doi.org/10.1073/pnas.112203099
  7. Food Chem Toxicol v.36 Induction of rat pancreatic glutathione S-transferase and quinine reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts Wallig M.A.;Kingston S.;Staack R.;Jeffery E.H. https://doi.org/10.1016/S0278-6915(97)00156-7
  8. Nutr Cancer v.33 Effects of isothiocyanate on growth and metaststicity of B16-F10 melanoma cells Sasaki,T.;Kudoh K.;Uda,Y.;Ozawa,Y.;Shimizu,J.;Kanke,Y.;Takita,T. https://doi.org/10.1080/01635589909514751
  9. Carcinogenesis v.21 7-methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase Ⅱ enzymes Rose P.;Faulkner K.;Williamson G.;Mithen R. https://doi.org/10.1093/carcin/21.11.1983
  10. Food Chem Toxicol v.40 Protective effects of Brussels sprouts towards B[a]P-induced DNA damage: a model study with the single-cell gel electrophoresis (SCGE)/HepG2 assay Laky B.;Knasmuller S.;Gminski R.;Mersch Sunderman V.;Scharf G.;Verkerk R.;Freywald C.;Uhl M.;Kassie F. https://doi.org/10.1016/S0278-6915(02)00031-5
  11. Carcinogenesis v.24 Synergy between sulforaphane and selenium in the induction of thioredoxin reductase I requires both transcriptional and translational modulation Zhang J.;Svehlikova V.;Bao Y.;Howie A.F.;Beckett G.J.;Williamson G. https://doi.org/10.1093/carcin/24.3.497
  12. Drug Metab Rev v.32 Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism Hecht S. https://doi.org/10.1081/DMR-100102342
  13. Carcinogenesis v.21 Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse Sticha K.R.;Starez M.E.;Wang M.;Liang H.;Kenny P.M.;Hecht S.S. https://doi.org/10.1093/carcin/21.9.1711
  14. Cancer Res v.51 Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats Chung F.L.;Kelloff G.;Steele V.;Pittman B.;Zang E.;Jiao D.;Rigorty J.;Choi C.I.;Rivensen A.
  15. Biochem Pharmacol v.60 Studies on the metabolism of the inhibition of human leukemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro Xu K.;Thornalley P.J. https://doi.org/10.1016/S0006-2952(00)00319-1
  16. J Natl Prod v.60 Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase Ⅱ enzyme, quinine reductase Chang L.C.;Gerhauser C.;Song L.;Farnsworth N.R.;Pezzuto J.M.;Kinghorn A.D. https://doi.org/10.1021/np970236p
  17. Anal Biochem v.239 Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol Zhang Y.;Wade K.L.;Prestera T.;Talalay P. https://doi.org/10.1006/abio.1996.0311
  18. Curr Drug Metab v.3 Isothiocyanantes as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans Conaway C.C.;Yang Y.M.;Chung F.L. https://doi.org/10.2174/1389200023337496
  19. Adv Agron v.61 Control of soil-borne plant pests using glucosinolate-containing plants Brown P.D.;Morra M.J. https://doi.org/10.1016/S0065-2113(08)60664-1
  20. Plant Sci v.85 Myrosinase is localized to the interior of myrosin grains and is not associated to the surrounding tonoplast membrane Hoglund A.S.;Lenman M.;Rask L. https://doi.org/10.1016/0168-9452(92)90112-Y
  21. Cancer Letters v.155 The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica on 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in mice Yano T.;Yajima S.;Virgona N.;Yano Y.;Otani S.;Kumagai H.;Sakurai H.;Kishimoto M.;Ichikawa T. https://doi.org/10.1016/S0304-3835(00)00364-5
  22. J Agric Food Chem v.50 Direct and simultaneous analysis of and allyl isothiocyanate in mustard samples by high-performance liquid chromatograph Tsao R.;Yu Q.;Potter J.;Chiba M. https://doi.org/10.1021/jf0200523
  23. Toxicologist v.15 Cyanohydroxybutan, a cruciferous nitrile, induces hepatic and pancreatic glutathione S-transferase in rats March T.;Jeffery E.;Walling M.
  24. Carcinogenesis v.13 Effects of phenylisothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzyme introsamine metabolism in rats Guo Z.;Smith T.Z.;Wang E.;Sadrich N.;Ma Q.;Thomas P.E.;Vang C.S. https://doi.org/10.1093/carcin/13.12.2205
  25. J Agric Food Chem v.50 Phase Ⅱ enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation Wettasinghe M.;Bolling B.;Plhak L.;Xiao H.;Parkin K. https://doi.org/10.1021/jf020575a

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