Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Serological Response of Puppies to the Selected Canine Vaccines and Vaccination Schedules against Canine Distemper Virus

CDV 함유 혼합백신과 예방접종 스케줄에 따른 강아지의 면역반응

  • Kim, Doo (Department of Veterinary Medicine, Kangwon National University) ;
  • Ahn, So-jeo (Department of Veterinary Medicine, Kangwon National University) ;
  • Jeoung, Seok-young (Department of Veterinary Medicine, Kangwon National University) ;
  • Hwang, Jae-woong (Department of Veterinary Medicine, Kangwon National University) ;
  • Pak, Son-il (Department of Veterinary Medicine, Kangwon National University)
  • Published : 2004.06.01
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Abstract

This study was undertaken to compare the serological response of dogs to four commercially available combination vaccines and three different vaccination schedules to canine distemper virus (CDV). A total of 120 healthy puppies (20 puppies per group) at 6 weeks of age were randomly assigned to one of four vaccines [C, G, K, and V (or V3) groups] and one of vaccination schedules [V2 and V4 groups]. At six, nine, and 12 weeks of age, puppies in each group were vaccinated with one of four combination vaccines subcutaneously. And puppies in V2 and V4 groups were vaccinated with V vaccine every 2 weeks and 4 weeks, respectively. The serological responses to CDV component of the vaccines were determined by measuring SN titers. The immunogenicity of V vaccine was superior to the other vaccines and optimum vaccination schedule was 3 times vaccination with 3 weeks-interval starting vaccination at 6 weeks of age. Although puppies were vaccinated at 6 weeks of age, the geometric mean CDV titers of puppies in all groups by 9 weeks of age were under the protective level. Therefore, prophylactic measures should include isolation of young dogs from the dog population until vaccination can be expected to provide protection.

본 연구에서는 우리나라 실정에 맞는 개 디스템퍼에 대한 예방접종 프로토콜을 마련하기 위하여, 국내에서 사용 중인 4종류의 상업용 백신과 3 가지의 예방접종 스케줄에 따른 강아지의 면역형성 능력을 비교 평가하였다. 생후 6주령에 예방접종을 실시하기 위하여 동물병원에 내원한 120두의 강아지를 4종류의 백신[C, G, K, V (또는 V3)군]과 예방접종 스케줄(2, V4 군)에 따라 20두씩 임의배치 하여 C, G, K, V(또는 3)군은 3주 간격으로 3회(6, 9, 12주), V2 군은 5회(6, 8, 10, 12, 14주), V4 군은 3회(6, 10, 14주)에 피하로 예방접종을 실시하였다. 초유를 섭취한 7마리 강아지의 모체이행 항체의 소장상태를 확인한 결과 모체이행항체는 생후 6주령에 방어수준 이하로 떨어졌다. 백신에 따른 면역형성능에서 V 백신의 면역형성 능력이 다른 백신보다 우수하였으며 백신 종류에 따라 면역형성 능력에 차이가 인정되어 사용되는 백신의 효능을 주기적으로 평가하여야 할 것으로 판단되었다. 그리고 가장 효과적인 예방접종 스케줄은 6주령에 예방접종을 시작하여 3주 간격으로 3회 접종하는 것으로 판단되었다. 그러나 예방접종을 실시한 모든 군의 대부분의 강아지는 생후 9주령까지 항체가 수준이 방어수준 이하로 나타나 개 디스템퍼의 감염을 예방하기 위하여 이 시기까지는 감영위험성이 높은 곳에 노출되는 것을 피해야 할 것으로 생각되었다.

Keywords

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