Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Kimchi on Stomach and Colon Health of Helicobacter pylori-Infected Volunteers

  • Kil, Jeung-Ha (Department of Food Science and Nutrition, Pusan National University) ;
  • Jung, Keun-Ok (Department of Food Science and Nutrition, Pusan National University) ;
  • Lee, Hyo-Sun (Department of Preventive and Occupation Medicin) ;
  • Hwang, In-Kyung (Department of Preventive and Occupation Medicin) ;
  • Kim, Yun-Jin (Department of Family Medicine, Colloge of Medicine, Pusan National University) ;
  • Park, Kun-Young (Department of Food Science and Nutrition, Pusan National University)
  • Published : 2004.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of kimchis intake on Helicobacter pylori infection in the stomach, the counts of lactic acid bacteria in the large intestine, and bacterial enzymes ($\beta$-glucosidase, $\beta$-glucuronidase) and pH in feces were examined. A total of 20 participants (age range 34 ∼ 57) were assessed for H. pylori infection status by Be urea breath test. Fourteen participants were eliminated because they were H. pylori-negative. This study consisted of 4 consecutive phase, each of which lasted 4 weeks. Three hundred grams of kimchi were administered to H. pylori-infected subjects during the kimchi phase, followed by 4 weeks of control phase. During the control phase, subjects consumed 60 g of kimchi, the minimum amount in their customary diets. All participants were found to be H. pylori-positive during all experimental periods. During the kimchi phase, delta over baseline (DOB) level was lower than during the control phase, although significant difference between the kimchi and control phases were not found (p=0.9439). However, the counts of Lactobacillus sp. and Leuconostoc sp. significantly (p < 0.0005) increased during the kimchi phase. $\beta$-Glucosidase and $\beta$-glucuronidase activities and pH were significantly decreased by kimchi intake compared to control (p=0.000l). These results suggested that kimchi consumption did not show any therapeutic effect on H. pylori in the stomach. However, kimchi seemed to be a good food for colon health, since it increased the beneficial bacteria such as lactobacillus and decreased toxic enzyme ($\beta$-glucosidase and $\beta$-glucuronidase) activity and pH.

Keywords

References

  1. Environ Muta Carcino v.17 Inhibitory effect of kimchi extract on mutagenesis of aflatoxin B1 Hwang SY;Hur YM;Choi YH;Rhee SH;Park KY;Lee WH
  2. J Food Sci Nutr v.3 Effects of kimchi extracts on interleukin-2 production and natural killer cell activity in mice Kim KH;Kim SH;Rhee SH;Park KY
  3. J Food Sci Nutr v.1 Effects of kimchi extract on the developement of multicellular structures from rat mammary organoids cultured in matrigel Kim ND;Hur YM;Rhee SH;Park KY
  4. J Food Sci Nutr v.2 Inhibitory effects of kimchi extracts on carcinogen-induced cytotoxicity and transformation in C3H/10T1/2 cell Choi MW;Kim KH;Kim SH;Park KY
  5. J Koran Soc Food Nutr v.24 The nutritional evaluation, and antimutagenic and anticancer effects of kimchi Park KY
  6. J Korean Soc Food Sci Nutr v.26 Effects of kimchi extracts on the growth of sarcoma-180 cells and phagocytic activity of mice Choi MW;Kim KH;Park KY
  7. Environ Muta Carcino v.8 Effect of L-ascorbic acid of the mutagenicity of aflatoxin B₁in the Salmonella assay system Park KY;Kweon MH;Baik HS;Cheigh HS
  8. Semin Oncology v.10 Vitamin C and cancer prevention Bright-See E
  9. Carcinogenesis v.16 In vivo antimutagenic activity of beta-carotene in rat spleen lymphocytes Aidoo A;Lyn-Cook LE;Lensing S;Bishop ME;Wamer W https://doi.org/10.1093/carcin/16.9.2237
  10. J Agric Food Chem v.40 Content of potentially anticarcinogenic flavonoids of 28 vegetables 9 fruits commonly consumed in the Netherlands Hertog MGL;Hollman PCH;Katan MB https://doi.org/10.1021/jf00024a011
  11. Gastroenterology v.102 Hypothesis on the pathogenesis and natural history of Helicobacter pylori-induced inflammation Balser MJ
  12. Br Med J v.302 Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation Forman D;Newell DG;Fullerton F;Yarnell JW;Stacey AR;Wald N;Sitas F https://doi.org/10.1136/bmj.302.6788.1302
  13. Appl Environ Microbiol v.66 Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori O'Gara EA;Hill DJ;Maslin DJ https://doi.org/10.1128/AEM.66.5.2269-2273.2000
  14. FEMS Immunol Med Microbiol v.13 Inhibition of Helicobacter pylori by garlic extract (Allium sativum) Cellini L;Di Campli E;Masulli M;Di Bartolomeo S;Allocati N https://doi.org/10.1111/j.1574-695X.1996.tb00251.x
  15. Acta Medica (Hradec Kralove) v.44 Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin Kockar C;Ozturk M;Bavbek N
  16. Trop Gastroenterol v.12 Inhibitory effect of natural honey on Helicobacter pylori Ali AT;Chowdhury MN;al Humayyd MS
  17. FEMS Microbiol Lett v.146 Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pylori Jones NL;Shabib S;Sherman PM https://doi.org/10.1111/j.1574-6968.1997.tb10197.x
  18. Scand J Gastroenterol v.32 High prevalence of duodenal ulcer and gastric cancer in dyspeptic patients in koraa Malaty HM;Kim JG;El-Zimaity HM;Graham DY https://doi.org/10.3109/00365529708996529
  19. Am J Epidemiol v.143 Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults Malaty HM;Kim JG;Kim SD;Graham DY https://doi.org/10.1093/oxfordjournals.aje.a008736
  20. Crit Rev Toxicol v.16 The effect of diet on the mammalian gut flora and its metabolic activites Rowland ER;Wise A https://doi.org/10.3109/10408448509041324
  21. Medical importance of the normal microflora Colon cancer: The potential involvement of the normal microflora Birbeck J;GW Tannock(ed.)
  22. Kimchi Sci Industry v.2 Regular intake of kimchi prevents colon cancer Oh YJ;Hwang IJ;Leitzmann C
  23. Nutraceut Food v.8 Effect of kimchi and its ingredients on the growth of Helicobacter pylori Jung KO;Kil JH;Kim KH;Park KY https://doi.org/10.3746/jfn.2003.8.2.149
  24. Clin Biochem v.32 Clinical validation of the $Helikit^{TM}$: A 13C urea breath test used for the diagnosis of Helicobacter pylori infection Mock T;Alberta E https://doi.org/10.1016/S0009-9120(98)00082-4
  25. J Koran Soc Food Sci Nutr v.25 Selective media for isolation and enumeration of lactic acid bacteria from kimchi Lee MK;Park WS;Kang KH
  26. Cancer Res v.46 Effects of differing purified cellulose pectin, and hemicellulose fiber on faecal enzymes in 1,2-dimethyl-hydrazine-induced rat colon carcinogenesis Freeman HJ
  27. J Nutr v.124 Lactobacillus strain GG supplementation decreases colonic hydrolytic and reductive enzyme activties in healthy female adults Ling WH;Korpela R;Mykanen H;Salminen S;Hanninen O
  28. Gastroenterol v.109 Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection Cutler AF;Havstad S;Ma CK;Blaser MJ;Perez-Perez GI;Schubert TT https://doi.org/10.1016/0016-5085(95)90278-3
  29. J Pediatr v.131 Carbon 13-labeled urea breath test for the diagnosis of Hlicobacter pylori infection in children Rowland M;Lamber I;Gormally S;Daly LE;Thomas JE;Hetherington C;Durnin M;Drumm B https://doi.org/10.1016/S0022-3476(97)70026-X
  30. Z Gastroenterol v.32 Evaluation of clinical and home performance of the $^13C$-urea breath test modifications still meet the criteria for valid diagnosis of Helicobacter pylori infection Thijs WJ;Thijs JC;Kleibeuker JH;Elzinga H;Stellard F
  31. Dig Liver Dis v.34 no.SUP.2 Probiotics and Helicobacter pylori eradication Canducci F;Cremonini F;Armuzzi A;Di Caro S;Gabrielli M;Santarelli L;Nista E;Lupascu A;De Martini D;Gasbarrini A https://doi.org/10.1016/S1590-8658(02)80172-4
  32. Gastroenterology v.116 Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice Madsen KL;Doyle JS;Jewell LD;Tavernini MM;Fedorak RN https://doi.org/10.1016/S0016-5085(99)70013-2
  33. Medical importance and normal microflora The normal microflora and antibiotic-associated diarrhoea and colitis Borriello SP;Roffe C;Tannock GW(ed.)
  34. Korean J Food Sci Technol v.28 Effect of kimchi intake on the compotistion of human large intestinal bacteria Lee KE;Choi UH;Ji GE
  35. Acta Medica (Hradec Kralove) v.44 Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin Kockar C;Ozturk M;Bavbek N
  36. Res Vet Sci v.72 Effect of diet on markers of intestinal health in dogs Martineau B;Laflamme DP https://doi.org/10.1053/rvsc.2002.0548
  37. Res Vet Sci v.72 Effect of diet on markers of intestinal health in dogs Martineau B;Laflamme DP https://doi.org/10.1053/rvsc.2002.0548

Cited by

  1. Purification and Identification of Inhibitory Compounds from Cheongmoknosang Mulberry Leaves (Morus alba. L.) on Helicobacter pylori vol.52, pp.2, 2009, https://doi.org/10.3839/jabc.2009.012
  2. Isolation and Identification of Antimicrobial Compounds against Helicobacter pylori from Rosemary (Rosmarinus officinalis L.) Extracts vol.54, pp.3, 2011, https://doi.org/10.3839/jabc.2011.027
  3. Health Benefits of Kimchi (Korean Fermented Vegetables) as a Probiotic Food vol.17, pp.1, 2014, https://doi.org/10.1089/jmf.2013.3083
  4. Quality Characteristics of White Bread Amended with Rosa multiflora Thunberg Extracts with Inhibitory Activity against Helicobacter pylori vol.41, pp.10, 2012, https://doi.org/10.3746/jkfn.2012.41.10.1431
  5. Kimchi and Other Widely Consumed Traditional Fermented Foods of Korea: A Review vol.7, 2016, https://doi.org/10.3389/fmicb.2016.01493
  6. Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease vol.11, pp.8, 2004, https://doi.org/10.3390/nu11081806
  7. Dietary pattern, dietary total antioxidant capacity, and dyslipidemia in Korean adults vol.18, pp.1, 2004, https://doi.org/10.1186/s12937-019-0459-x