Antitumor Activity of Peptide Fraction from Traditional Korean Soy Sauce

  • Lee, Hong-Jin (Department of Food Science & Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Ki-Won (Department of Food Science & Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Kyoung-Heon (Division of Food Science, College of Life and Environmental Sciences, Korea University) ;
  • Kim, Hyun-Kyung (Department of Food Science & Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Hyong-Joo (Department of Food Science & Technology, School of Agricultural Biotechnology, Seoul National University)
  • 발행 : 2004.06.01

초록

Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-l human colon cancer cells with $IC_{50}$ values of 11, 50, and $50\mug/ml$, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.

키워드

참고문헌

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