동아시아식생활학회지 (Journal of the East Asian Society of Dietary Life)

  • 제14권3호
  • /
  • Pages.288-293
  • /
  • 2004
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  • 1225-6781(pISSN)
  • /
  • 2288-8802(eISSN)
동아시아식생활학회 (The East Asian Society of Dietary Life)
권호 표지

발효콩 추출물의 항돌연변이원성 및 세포독성 효과

Antimutagenic and Cytotoxicity Effects of Fermented Soybean Extract

  • 함승시 (강원대학교 바이오산업공학부) ;
  • 최승필 (강원대학교 바이오산업공학부) ;
  • 이효진 (강원대학교 바이오산업공학부) ;
  • 문선영 (강원대학교 바이오산업공학부) ;
  • 김수현 (강원대학교 바이오산업공학부) ;
  • 이득식 (동해대학교 외식산업학과)
  • 발행 : 2004.06.01
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초록

This study was carried out to determine the antimutagenic and anticancer effects of fermented soybean using Ames test and cytotoxicity, respectively. The ethyl acetate fraction (200 g/plate) of fermented soybean in the Salmonella typhimurium TA100 strain showed 86.6% of inhibition rate against the mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). In addition, the suppression of ethyl acetate fraction with same concentration of fermented soybean in the Salmonella typhimurium TA98 and TAI00 strains showed 82.4% and 90.8% inhibition against 3-amino-l,4-dimethyl-5H-pyrido-(4,3-b)indol (Trp-P-l), respectively. The cytotoxicity effects of fermented soybean against the cell lines with human lung carcinoma (A549), human gastric carcinoma (AGS) and human breast adenocarcinoma (MCF-7) were inhibited with the increase of the extract concentration. The treatment of 1.0 mg/mL ethyl acetate fraction of fermented soybean showed strong cytotoxicities of 71.6%, 91.5% and 80.7% against A549, AGS and MCF-7, respectively.

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