Journal of the Korea Institute of Military Science and Technology (한국군사과학기술학회지)

The Korea Institute of Military Science and Technology (한국군사과학기술학회)
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Discovery of Protein Biomarkers for Infected Bacillus anthracis Spores in Using Proteomic Analysis

프로테오믹스를 이용한 탄저균 아포 감염에 대한 바이오마커 탐색

  • 서귀문 (한양대학교 생화학 및 분자생물학과) ;
  • 남덕화 (한양대학교 생화학 및 분자생물학과) ;
  • 오광근 ((주)셀엔젠) ;
  • 김성주 (한양대학교 생화학 및 분자생물학과) ;
  • 김지천 (한양대학교 생화학 및 분자생물학과) ;
  • 채영규 (한양대학교 생화학 및 분자생물학과)
  • Published : 2004.03.01
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Abstract

The etiological agent is Bacillus anthracis, a gram-positive rod-shaped bacterium able to form spores. In order to elucidate the mechanism of infecttion on human macrophage cells, we performed two-dimensional electrophoresis and MALDI-TOF analysis using the infected human macrophage cells with the spores of B. anthracis Sterne of inactivated B. anthracis Sterne. We identified 9 proteins which related to the infection of Bacillus anthracis spores on human macrophage cells at the early stage events. Maybe nine proteins will be bio-markers and vaccine candidates to the Bacillus anthracis spore infection.

Keywords

References

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