Journal of Microbiology and Biotechnology

  • 제14권2호
  • /
  • Pages.411-414
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  • 2004
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

In Vivo Antitumor Activity of Hydrophilic Arginine-Conjugated Linoleic Acid Complex

  • Kim, Young-Jun (Department of Food and Biotechnology, Korea University) ;
  • Lee, Ki-Won (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Dae-Ok (Department of Food Science and Technology, Cornell University) ;
  • Kim, Tae-Wan (Department of Animal Science, Cornell University) ;
  • Lee, Seong-Kweon (Lipozen Inc.) ;
  • Lee, Hyong-Joo (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University)
  • 발행 : 2004.04.01
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초록

Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic form of CLA. Mouse forestomach cancer was induced by gavage with benzo(a)pyrene (B(a)p) for 4-weeks prior to Arg-CLA (0.2 and 0.5％) feeding. Complete necropsies were performed to determine the number, size and locations of all the forestomach tumors at 20 weeks post-B(a)P administration. All mice in the B(a)P group developed tumors, and tumor incidences were decreased by 31 ％ and 44％ in 0.2％ and 0.5％ Arg-CLA-fed groups, respectively, whereas no decrease was observed when Arg or com oil was given alone. Our results suggest that Arg-CLA suppresses mouse forestomach cancer.

키워드

참고문헌

  1. Nutr. Cancer v.26 Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion Belury,M.A.;K.P.Nickel;C.E.Bird;Y.M.Wu https://doi.org/10.1080/01635589609514471
  2. Diabetologia v.45 L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in type ii diabetic patients Cassone Faldetta, M.;O.Laurenti;G.Desideri;M.C.Bravi;O. De Luca;M.C.Marinucci;G. De Mattia;C.Ferri https://doi.org/10.1007/s00125-002-0854-1
  3. Anticancer Res. v.18 Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice Cesano,A.;S.Visonneau;J.A.Scimeca;D.Kritchevsky;D.Santoli
  4. J. Food Compos. Anal. v.5 Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens Chin,S.F.;W.Liu;J.M.Storkson;Y.L.Ha;M.Pariza https://doi.org/10.1016/0889-1575(92)90037-K
  5. Carcinogenesis v.20 Molecular epidemiology, pathogenesis and prevention of gastric cancer Christian,T.;K.H.Stadtlander;J.W.Waterbor https://doi.org/10.1093/carcin/20.12.2195
  6. J. Lipid Res. v.43 Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse Clement,L.;H.Poirier;I.Niot;V.Bocher;M.Guerre-Millo;S.Krief;B.Staels;P.Besnard https://doi.org/10.1194/jlr.M20008-JLR200
  7. Cancer Res. v.50 Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid Ha,Y.L.;J.Storkson;M.W.Pariza
  8. Cancer Res. v.51 Mammary cancer prevention by conjugated dienoic derivative of linoleic acid Ip,C.;S.F.Chin;J.A.Scimeca;M.W.Pariza
  9. Nutr. Cancer v.24 Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention Ip,C.;J.A.Scimeca;H.Thompson https://doi.org/10.1080/01635589509514413
  10. Exp. Cell Res. v.250 Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells on primary culture Ip,M.M.;P.A.Masso-Welch;S.F.Shoemaker;W.K.Shea-Eaton;C.Ip https://doi.org/10.1006/excr.1999.4499
  11. J. Microbiol. Biotechnol. v.12 Antitumor activity of Lactobacillus plantarum cytoplasm on teratocarcinoma-bearing mice Kim,J.Y.;H.J.Woo;K.H.Kim;E.R.Kim;H.K.Jung;H.N.Juhn;H.J.Lee
  12. J. Food Sci. v.68 The production of high-purity conjugated linoleic acid CLA using two-step urea inclusion crystallization and hydrophilic arginine-CLA complex Kim,Y.J.;K.W.Lee;S.Lee;H.Kim;H.J.Lee https://doi.org/10.1111/j.1365-2621.2003.tb06999.x
  13. J. Microbiol. Biotechnol. v.12 Antitumor activity of chitosan oligosaccharides produced in ultrafiltration membrane reactor system Jeon,Y.J.;S.K.Kim
  14. Mol. Pharmacol. v.61 Functional and analytical evidence for scavenging of oxygen radicals by L-arginine Lass,A.;A.Suessenbacher;G.Wolkart;B.Mayer;B.Friedrich https://doi.org/10.1124/mol.61.5.1081
  15. Carcinogenesis v.16 Protection of conjugated linoletic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat - a study of inhibitory mechanisms Liew,C.;H.A.J.Schut;S.F.Chin;M.W.Pariza;R.H.Dashwood https://doi.org/10.1093/carcin/16.12.3037
  16. Lipids v.32 Conjugated linoleic acids modulation of phorbol ester-induced events in murine keratinocytes Liu,K.L.;M.A.Belury https://doi.org/10.1007/s11745-997-0092-2
  17. J. Microbiol. Biotechnol. v.10 Cytotoxicity of shikonin metabolites with biotransformation of human intestinal bacteria Min,B.S.;M.R.Meselhy;M.Hattori;H.M.Kim;Y.H.Kim
  18. Pharmacol. Rev. v.43 Nitric oxide physiology, pathophysioloy and pharmacology Moncada,S.;R.M.J.Palmer;E.A.Higgs
  19. Br. J. Nutr. v.86 Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: A possible mechanism of the anticarcinogenic effect by CLA Park,H.S.;J.H.Ryu;Y.L.Ha;J.H.Park https://doi.org/10.1079/BJN2001445
  20. J. Bacteriol. v.88 Biohydrogenation of unsaturated fatty acids by rumen bacteria Polan,C.E.;J.J.McNeill;S.B.Tove
  21. J. Microbiol. Biotechnol. v.11 In vitro cancer chemopreventive activities of polysaccharides from soybeans fermented with Phellinus igniarius or Agrocybe cylindracea Shon,Y.;K.Nam
  22. Diabetes v.49 Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice Tsuboyama-Kasaoka,N.;M.Takahashi;K.Tanemura;H.J.Kim;T.Tange;H.Okuyama;M.Kasai;S.Ikemoto;O.Ezaki https://doi.org/10.2337/diabetes.49.9.1534