Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Effect of Porphyra tenera Extract on Serum Lipid Content in Ovariectomized Rats

김 추출물이 갱년기 장애 유도 흰쥐의 혈 중 지질 변화에 미치는 영향

  • 한희선 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터) ;
  • 배송자 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터) ;
  • 김미향 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터)
  • Published : 2004.04.01
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Abstract

The aim of this study is to evaluate the effect of Porphyra tenera (PT) extract on serum lipids content in ovariectomized rats. From day 3 until 42 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovarjectomized rats supplemented with PT at 50 mg/kg bw/day (OVX-PT50), 200 mg/kg bw/day (OVX-PT200). The PT ethanol extract were orally administrated at 1 m1 per day. Body weight gain, food intake and food efficiency ratio were not significantly different between groups. Although total-cholesterol was increased in OVX-control, supplementation with the PT decreased the level of cholesterol in serum. Especially, it was significantly decreased in OVX-PI50 (p＜0.05). Triglyceride was significantly decreased to almost all of groups supplemented with PT (p＜0.05). The levels of HDL-cholesterol was higher in PT extract group than OVX-control. These results suggest that supplementation with the PT extract positively influenced on lipid concentration in serum. Consequently, we expect that PT extract decrease risk of cardiovascular diseases by postmenopausal.

폐경과 더불어 시작되는 폐경기의 에스트로겐 변화로 발생되는 건강 문제 중 심혈관계질환이 문제점으로 대두되고 있다. 그러므로 본 연구는 갱년기 장애 시 유발되는 체내 지질 함량 증가에 있어서 김 추출물이 미치는 영향을 조사하기 위해 인위적 폐경을 유발시킬 수 있는 난소 절제 쥐에서 김 추출물의 혈 중 지질 함량 변화에 미치는 영향을 검토하였다. 그 결과 난소 절제에 의한 total-cholesterol의 증가가 김 추출물을 투여함으로써 감소하는 경향을 보였다. 특히 김 추출물 50 mg/kg bw/day에서 유의적으로 감소하였다. 혈 중성 지방에서는 김 추출물 농도별 투여한 OVX-PT50, OVX-PT200 모든 군에서 난소를 절제하지 않은 Sham군과 비슷한 수준으로 감소하는 경향을 보였고, 또한 혈 중 HDL-cholesterol은 김 추출물 투여로 인해 난소 절제한 군과 비교해서 높은 경향을 나타내었다. 이상의 결과는 갱년기 장애 시 유발되는 지질 대사 이상으로 오는 심혈관계질환에 김의 섭취가 유익한 결과를 줄 것으로 사료되며, 또한 잘못된 식습관으로 오는 비만이나 심혈관계 질환에도 유익한 효과를 가져다 줄 것으로 기대된다.

Keywords

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