Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
권호 표지

The Search of fig Pheromonal Odorants for Biostimulation Control System Technologies: I. Ligand Based Molecular Shape Similarity of 5$\alpha$-androst-16-en-3-one Analogous and Their Physicochemical Parameters

생물학적 자극 통제 수단으로서 활용하기 위한 돼지 페로몬성 냄새 물질의 탐색: I. 5$\alpha$-androst-16-en-3-one 유사체들의 리간드에 기초한 분자 유사성과 물리화학 파라미터

  • 성낙도 (충남대학교 응용생물화학부/형질전환 복제돼지 연구센터) ;
  • 김철호 (충남대학교 농업경제학과) ;
  • 진동일 (충남대학교 동물자원학부) ;
  • 박창식 (충남대학교 동물자원학부)
  • Published : 2004.03.01
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Abstract

To search a new porcine pheromonal odorants, this research for biostimulation and role of pheromone was augmented by means of "control system technologies" to offer a potentially useful and practical way to improve reproductive efficiency in livestock species. Therefore the 13 physicochemical parameters such as similarity indice (S), hydrophobicity (logP) and van der Waals molecule volume (MV) etc. of 54 steroid analogues, which are analogous of substrate molecules, 5$\alpha$-androst-16-en-3-one (P1) and 5$\alpha$-androst-16-en-3-ol (P2) of lipocalin as receptor of pig pheromones were calculated and discussed. The physicochemical properties of these steroid analogues were mainly followed by steric dissimilar of A and D ring in steroid nucleus. And we found that from correlation with S values and MV constants of molecules, the more MV constants are small, the more S values tend to approach 1. Based on this results, the S-values of 4-androsten-3,17-dione (P1-1) and 5 $\alpha$ -androstan-3-one (P2-1) were 1.0, respectively. The two compounds of them were chosen because they showed the same value each other at a side of hydrophobicity, molar refractivity and molecular volume. It is expected that the new two compounds will be able to substitute for P1 and P2, porcine pheromonal odorants.

Keywords

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