대한지역사회영양학회지 (Korean Journal of Community Nutrition)

대한지역사회영양학회 (The Korean Society of Community Nutrition)
권호 표지

임신 말 모체와 제대혈의 Retinol, $\beta-Carotene,\;\alpha$-Tocopherol의 농도 및 임신결과와의 상관성

$\beta-Carotene,\;\alpha$-Tocopherol Concentrations in Maternal-Umbilical Cord Plasma and Their Relationships to Pregnancy Outcome

  • 이금주 (성신여자대학교 식품영양학과) ;
  • 이민숙 (성신여자대학교 식품영양학과) ;
  • 안홍석 (성신여자대학교 식품영양학과)
  • 발행 : 2004.04.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The purpose of this study was to evaluate the intake of antioxidant vitamins and plasma concentrations of those in 60 maternal-infant pairs (30 in normal term delivery group, NT; 30 in preform delivery group, PT). We also investigated the relationship between vitamin levels of maternal-umbilical cord plasma and pregnancy outcome. Mean energy intakes of NT and PT pregnant women were 93.2% and 85.4%, and their protein intakes were 113.3% and 110.9% of the recommended dietary allowance (RDA), respectively. While vitamin A intakes were only 51.2% and 39.6% of the RDA in NT and PT pregnant women. The vitamin E intake was about 50% of the RDA (NT 6.27 mg, PT 7.78 mg). The levels of retinol in maternal plasma of NT and PT were $1.51\mumol/\ell\;and\;1.43\mumol/\ell$, respectively. The retinol levels in umbilical cord plasma in NT and PT were $0.72\mumol/\ell\;and\;0.61\mumol/\ell$, respectively. The level of $\beta-carotene$in maternal plasma of NT was 0.49 $\mu$mol/$\ell$, significantly (p ＜ 0.01) higher than that of PT ($0.31\mumol/\ell$).The $\beta-carotene$ of umbilical cord plasma of NT and PT were $0.702\mumol/\ell\;and\;0.01\mumol/\ell$, respectively. The plasma $\alpha$-tocopherol of maternal of NT and PT were $0.72\mumol/\ell\;and\;0.01\mumol/\ell\;29.51 /mumol/\ell\; and 27.17\mumol/\ell,\;respectively.\; The $\alpha$-tocopherol of umbilical cord plasma of NT and PT were $4.16\mumol/\ell\;and\;3.80\mumol/\ell$, respectively. The antioxidant vitamin levels (retinol, $\beta-carotene,\;and\;\alpha$-tocopherol) in maternal plasma were significantly higher (p＜0.0001) than those in umbilical cord plasma. However, there was no correlation between the vitamin levels in maternal plasma and those in umbilical cord plasma. The maternal plasma $\beta$-carotene level showed a positive correlation to gestational age. Also Apgar score at 1 min produced a positive correlation to maternal plasma $\beta$-carotene level.

키워드

참고문헌

  1. Apgar J, Dulin A, Kramer T, Smith JC (1991): Reduced survival of neonates due to vitamin A deficiency during pregnancy in the gunia pig. Proc Soc Exp Biol Med 197: 56-58
  2. Baydas G, Karatas F, Gursu MF, Bozkurt HA, Ilhan N, Yasar A, Canatan H (2002): Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status. Arch Med Res 33(3): 276-280
  3. Ceriello A, Bortolotti N, Pirisi M, Crescentini A, Tonutti L, Motz E, Russo A, Giacomello R, Stel G, Taboga C (1997): Total plasma antioxi-dant capacity predicts thrombosis-prone status in NIDDM patients. Diabetes Care 20(10): 1589-1593 https://doi.org/10.2337/diacare.20.10.1589
  4. Chan V, Greenough A, Cheeseman P, Gamsu HR (1993): Vitamin A status in preterm and term infants at birth. J Perinat Med 2 (1): 59-62
  5. Coutsoudis A, Adhikari M, Coovadia HM (1995): Serum vitamin A(retinol) concenrtations and association with respiratory disease in premature infants. J Trop Pediatr 41(4): 230-233 https://doi.org/10.1093/tropej/41.4.230
  6. Frank L, Croseclose EE (1984): Preparation for birth into an $O_2$ rich environment: the antioxidant enzymes in the developing rabbit lung. Pediatr Res 18(3): 240-244 https://doi.org/10.1203/00006450-198403000-00004
  7. Frank L, Sosenko ORS (1987): Prenatal development of lung antioxi-dant enzymes in four species. J Pediatr 110: 106-110 https://doi.org/10.1016/S0022-3476(87)80300-1
  8. Ganguly C, Mukherjee KL (1988): Relationship between maternal serum vitamin A and vitamin status of the corresponding fetus. J Trap Pediar 34: 313-315 https://doi.org/10.1093/tropej/34.6.313
  9. Ghebremeskel K, Burns L, Burden TJ, Harbige L, Costeloe K, Powell (1994): Vitamin A and related essential nutrients in cord blood relationships with anthropometric measurements at birth. Early Human Development 39(3): 177-188 https://doi.org/10.1016/0378-3782(94)90196-1
  10. Gomez R, Ghezzi F, Romero R, Munoz H, Tolosa JE, Rojas I (1995): Trabajo de parto premature infeccion intraamnostica: aspectos dlinicos y funcion de las citocinas en el diagnostico y la fisiopato-logia. Clin Perinatal North Am 2: 267-326
  11. Greene HL, Moore ME, Phillips B, Franck L, Shulman RJ, Ament ME, Murrell JE, Chan MM, Said HM (1986): Evaluation of a pediatric multiple vitamin preparation for total arenteral nutrition. II. Blood levels of vitamin A, D and E. Pediatrics 77(4): 539-547
  12. Harrill I, Lynch L, Shipman D (1973): Nutritive values of foods selected during pregnancy. Am Diet Assoc 63: 164-167
  13. Hittner HM, Godio LB, Rodolph AJ, Adams JM, Garcia-Prats JA, Fri-endman Z, KAutz JA, Monaco WA (1981): Retrolental fibroplasia: efficacy of vitamin E in a double-blind clinical study of preterm infants. N Engl J Med 305: 1365-1371 https://doi.org/10.1056/NEJM198112033052301
  14. Ishihara M (1978): Studies on lipid peroxide of normal pregnant women and of patient with toxemia of pregnancy. Clin Chim Acta 84(1-2): 1-9
  15. Johnson AA, Knigh EM, Edwards CH, Oyemade UJ, Cole OJ, Westney OE, Westney LS, LAryea H, Jones S (1994): Dietary intakes, an-thropometric measurements and pregnancy outcomes. J Nutr 124(suppl): 936S-942S
  16. Jung HK, Jang NS, Song ES (1994): Riboflavin and pyridoxin nutri-tional status of newborns: A multiple regression analysis of its determining factors. Korean J Nutrition 27(4): 368-377
  17. Kang MH, Park EJ (2000): Effects of regular pysical execise habits on the activities of erythrocyte antioxidant enzyme and plasma total radical-trapping antioxidant potential in healthy male subjects. Korean J Nutr 33(3): 289-295
  18. Karp WB, Robertson AF (1986): Vitamin E in neonatology. Adv Pediatr 33: 127-147
  19. Katz A, West KP Jr, Khatry SK, Pradhan EK, Leelerq SC, Christion P, Wu LS, Adhikari RK, Shrestha SR, Sommer A (2000): Maternal low-dose vitamin A or $\beta$ -carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal. Am J Clin Nutr 71: 1570-1576
  20. Kelly FJ (1993): Free radical disorders of preterm infants. Br Med Bull 49(3): 668-678
  21. Kiely M, Cogan PF, Kearney PJ, Morrissey PA (1999): Concentrations of tocopherols and carotenoids in maternal and cord blood plasma. Eur J Clin Nutr 53(9): 711-715 https://doi.org/10.1038/sj.ejcn.1600838
  22. Kim EK, Lee KH (1998): Assessment of the intake and availability of dietary iron and nutrition knowledge in pregnant women. Korean J Community Nutrition 3(1): 53-61
  23. Kim EK, Lee KH (1999): Iron status in pregnant women and their newborn infants. Korean J Nutrition 32(7): 793-801
  24. Kim HL, Baeek JJ (1978): Afood and nutrient intake of the pregnant women in rural Korea. Korean J Community Nutrition 11: 19-25
  25. Kim HY, Kim NY, Kim SM (1994): Effect of maternal status on immu-nological substances in breast milk of Korean women. Korean J Community Nutrition 27(3): 263-271
  26. Lee GSR, Kim SJ, Kim SY, Kahung JM, Hur SY, Lee Y, Shin Jc, Kim EJ, Song SK, Kim SP (1998): Total antioxi-dant status in maternal and neonatal plasma according to delivery type. Council of Korea Obstetrics & Gynecology Practitioners 41(8): 2067-2071
  27. Lee LH, Hong HS (1983): Correlation of levels of hemoglobin and hematocrit with nutritional intakes and general environmental fac-tors of pregnant women among low income group in Seoul area. The Korean Home Economics Association, pp.51-64
  28. Lee MJ (1982): A study on the nutritional status of the pregnant and the lactating women and the newborn babies in Samchuk-Gun district. Ewha Women's University. A thesis for a Doctorate
  29. Lim HS, Kim HA (1998): Effects of maternal anemia on the iron status of the cord blood and pregnancy outcomes. Korean J Community Nutrition 3(4): 565-573
  30. Maseki M, Nishigaki, Hagilara M, Tumoda Y, Yagi K (1981): Lipid peroxide levels and lipid serum content of serum lipoprotein fractions of pregnant subjects with and without preeclampsia. Clin Chim Acta 155: 155-160
  31. Miller NJ, Rice-evans C, Davies MJ, Gopinathan V, Milner A (1993): A novel method for measuring antioxidant capacity and its appli-cant to monitoring the antioxidant status in premature neonates 84: 407-412
  32. Navarro J, Causse MB, Desquilbet N, Herve F, Lallemand D (1981): The vitamin status of low birth weight infants and their mothers. J Pediatr Gastroenterol Nutr 3: 744-748 https://doi.org/10.1097/00005176-198411000-00019
  33. Park SH, Ahn HS (1999): Dietary fat intake during pregnancy and serum lipid levels in mother and umbilical cord of full-term and preterm delivery. Korean J Nutrition 32(5): 577-584
  34. Procelli PJ, Greene HL, Adcock EW (1992): Retinol (vitamin A) and riboflavin (vitamin $B_2$) administration and metabolism in very low birth weight infants. Semin Perinatol 16(3): 170-180
  35. Robeles R, Palomino N, Robles A (2001): Oxidative stress in the neo-nate. Early Human Development 65: S75-81 https://doi.org/10.1016/S0378-3782(01)00209-2
  36. Samuel R, Gisela W, Mujahid A, Mark H, Thomas H (2000): Antioxi-dant capacity and oxygen radical disease in the preterm newborn. Arch Pediatr Adolesc Med 154: 544-548
  37. Sempos CT (1992): Some limitation of semiquantitative food frequancy questionnaire. Am J Epid 135: 1127-1132
  38. Seo JY, Kim WK, Choi BS (2001): The effects of regular exercise on nutrients intake and pregnancy outcome of pregnant women in daegu area. Korean J Nutr 34(8): 929-935
  39. Shah RS, Rajalakshmi R (1984): Vitamin A status of the newborn in relation to gestational age, body weight, and maternal nutritional status. Am J Clin Nutr 40: 794-780 https://doi.org/10.1093/ajcn/40.4.794
  40. Song YS, Kim SH (1989): Nutritional status of rural pregnant women in relation to physical condition of offspring at birth. Korean J Nutrition 22: 547-556
  41. Sowell AL, Huff DL, Yeager PR, Candill SP, Gunter EW (1994): Re-tinol, $\alpha$ -tocopherol, lutein/zeaxanthin, $\beta$ -crptoxanthin, Iycopene, $\alpha$ -carotene, trans- $\beta$ -carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multi-wavelength detection. Clin Chem 40(3): 411-416
  42. Sullivan JL (1988): Iron, plasma antioxidants, and the Oxygen radical disease of prematurity. Am J Dis Child 142: 1341-1344
  43. Tammela O, Aitola M, Ikonen S (1999): Cord blood concentrations of vitamin A in preterm infants. Early Human Development 56: 39-47 https://doi.org/10.1016/S0378-3782(99)00032-8
  44. Tamura T, Goldenberg RL, Johnston KE (1997): Serum concentrations of zinc, folate, vitamin A and E, and proteins, and their relation-ships to pregnancy outcome. Acta Obstet Gynecol Scand Suppl 165: 63-70
  45. Wang Y, Walsh SW, Guo J (1991): Maternal levels of prostcyclin, thromboxane, vitamin E, and peroxides throughout normal pre-gnancy. Am J Obstet Gynecol 165: 1690-1695 https://doi.org/10.1016/0002-9378(91)90016-K
  46. Whitsett JA (1981): Synthesis of 1, 25-Dihydroxyvitamin D3 by Hu-man Placenta in Vitro. J Clin Endocrinol Metabol 53: 484-488 https://doi.org/10.1210/jcem-53-3-484
  47. Worthington Roberts BS (1993): Nutrition in pregnancy and lactation (5th-ed), Mosby
  48. Wu SC, Chou YH (2001): Measurement of serum vitamin E isomers in fullterm and preterm infants. Chang Gung Med J 24(12): 793-798
  49. Yeum KJ, Ferland G, Party J, Russell RM (1998): Relationship of pla-sma carotenoids, retinol and tocopherols in mothers and newborn infants. J Am Coll Nutr 17(5): 442-447 https://doi.org/10.1080/07315724.1998.10718791
  50. Yu KH, Yoon JS (1999): A cross-sectional study of nutrient intakes by gestational age and pregnancy outcome (I). Korean J Nutrition 32(8): 877-886
  51. Yu KH, Yoon JS, Hahm YS (1999): A cross-sectional study of bioche-mical analysis and assessment of iron deficiency by gestational age (II). Korean J Nutrition 32(8): 887-896