대한의생명과학회지 (Biomedical Science Letters)
- 제10권1호
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- Pages.55-63
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- 2004
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
A Study on DNA Sequences and Mutation of Integrase Region of Korean-type Bovine Leukemia Virus (BLV) pol Gene
- Kwon, Oh-Sik (Department of Microbiology, Keimyung University) ;
- Kang, Jung-Soon (Molecular Structure Unit, KRIB) ;
- Park, Hyun-Jin (Radiation Cytogenetics Team, Radiological & Medical Sciences Research Center Korea Institute of Radiological & Medical Science) ;
- Yoo, Min (Department of Biology, Keimyung University)
- 발행 : 2004.03.01
초록
Bovine leukemia virus (BLV) is a causative agent for lymphoma disease in cattle including cows worldwide. BLV shares similar virion structure and characteristics with other retroviruses. The pol gene of the BLV genome produced reverse transcriptase (RT) and integrase (IN) for important roles for BLV genome integration into host cell chromosomes that is known to be coded in the 3' side of the BLV pol gene (one third portion). In this study, we have sequenced 978 bp in the 3' side of the BLV pol gene from BLV 10C3 in order to determine the BLV IN region of it. And we compared it to the nucleotide sequences of an Australian BLV isolate. As a result, nucleotide sequences of the IN region of the Korean-type BLV pol gene were mutated at a rate of 3.7%. We can confirm that the typical mutations are such as Arg (AGG)