Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Development of resistance to reinfection by Clonorchis sinensis in rats

  • Chung, Byung-Suk (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center) ;
  • Zhang, Hong-Man (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center, Division of Schistosomiasis, Guangxi Center of Disease Control and Prevention) ;
  • Choi, Min-Ho (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center) ;
  • Jeon, Deog-Kyu (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center) ;
  • Li, Shun-Yu (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center,Department of Parasitology, College of Medicine, Yanbian University) ;
  • Lee, Me-Jeong (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center) ;
  • Hong, Sung-Tae (Department of Parasitology and Tropical Medicien, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National Univeristy Medical Research Center)
  • Published : 2004.03.01
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Abstract

We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and reinfected. Worm recovery rate in reinfected animals was used to estimate resistance to reinfection. The determined resistance rates to reinfection in rats and hamsters were 97.7% and 10.3%, respectively. In rats, cure from the primary infection of C. sinensis increased resistant to reinfection, and the greatert the worm burden and the longer the duration of primary infection, the higher was the resistance rate. For primary infection doses of 10, 40 and 100 metacercariae per rat, the resistance rates were 87.4%, 93.8% and 98.4%, respectively. The resistance rates in rats after 2 or 8-week primary infection were 78.7% and 95.3%, respectively. All worms recovered from reinfected rats were immature. When cured rats were administered with methylprednisolone, resistance to reinfection became impaired. These findings indicate that rats develop a high degree of resistance to reinfection by C. sinensis after cure. The growths and maturations of reinfected worms were also impaired.

Keywords

References

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