Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Bile duct changes in rats reinfected with Clonorchis sinensis

  • Choi, Dong-Il (Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine, Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hong, Sung-Tae (Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine) ;
  • Li, Shun-Yu (Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine, Department of Parasitology, College of Medicine, Yanbian University) ;
  • Chung, Byung-Suk (Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine) ;
  • Lim, Jae-Hoon (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Soon-Hyung (Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine)
  • Published : 2004.03.01
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Abstract

This study describes an evaluation of the sonographic, cholangiographic, pathological, and immunological findings, and the protective effect shown by rats reinfected with Clonorchis sinensis. Eight experimental rat groups were, namely, a normal control, a primary infection control, a reinfection I (reinfection 7 week after treatment following 3-week infection), a reinfection II (reinfection 2 week after treatment following 8-week infection), a reinfection III (exploration of the intrahepatic bile ducts 1 week after reinfection 4 week after treatment following 4-week infection), a superinfection, a secondary infection control, and an infection following immunization group. Sonographic and cholangiographic findings showed moderate or marked dilatation of the bile duct confluence in the primary infection control, reinfection II, and secondary infection control groups. Juvenile worms survived in the intrahepatic bile ducts 1 week after reinfection following treatment in the reinfection III group. It was concluded that reinfecting juvenile worms found during the first week following reinfection failed to survive or grow further. Anatomical, pathophysiological, or immunological changes may induce protection from reinfection in rats.

Keywords

References

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