Outcome of Patch Angioplasty for Left Main Coronary Ostial Stenosis

좌주관상동맥 개구부 협착에서의 혈관성형술의 결과

  • Kang, Chang-Hyun (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Na, Chan-Young (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Seo, Hong-Joo (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Kim, Jae-Hyun (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Lee, Cheul (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Chang, Yoon-Hee (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Hwang, Seong-Wook (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Baek, Man-Jong (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Oh, Sam-Se (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute) ;
  • Kim, Woong-Han (Dept. of Thoracic and Cardiovascular Surgery, Seoul National University Hospital) ;
  • Lee, Young-Tak (Dept. of Thoracic and Cardiovascular Surgery, Samsung Medical Center, School of Medicine, Sunkyunkwan University) ;
  • Kim, Chong-Whan (Dept. of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute)
  • 강창현 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 나찬영 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 서홍주 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 김재현 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 이철 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 장윤희 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 황성욱 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 백만종 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 오삼세 (부천세종병원 흉부외과, 세종심장연구소) ;
  • 김웅한 (서울대학교 의과대학 흉부외과학교실) ;
  • 이영탁 (성균관대학교 의과대학 삼성서울병원 흉부외과) ;
  • 김종환 (부천세종병원 흉부외과, 세종심장연구소)
  • Published : 2004.01.01

Abstract

Background: Patch angioplasty is an alternative surgical procedure to coronary artery bypass grafting (CABG) for left main coronary ostial stenosis. The purpose of this study is to evaluate the outcome of patch angioplasty by analyzing the short-term and long-term results. Material and Method: Twenty nine patients who had undergone patch angioplasty due to left main coronary ostial stenosis between July 1991 and May 2003 were enrolled in the study. The mean age of the patients was 53.1 $\pm$12.5 years. There were 8 males and 21 females, and there were 12 female patients who had no risk factor for atherosclerosis. Twenty six (89.7%) patients showed isolated coronary ostial stenosis without any distal coronary lesion. Result: Anterior approach was used in 28 patients and superior approach was used in one patient. Transsection of the main pulmonary artery was used in one patient. Concomitant CABG was performed in 4 patients because of left anterior descending artery lesions in 3 patients and unstable postoperative hemodynamic status in one patient. Hospital mortality had occurred in one patient (3.4%) and late mortality also in one patient, therefore the overall 5 year survival rate was 91.2$\pm$6.1%. Seventeen coronary angiographies were done in 13 patients (44.8%) postoperatively. Two distal patch stenoses, 1 proximal patch stenosis, and 1 new right coronary ostial lesion were identified and 3 percutaneous interventions and 1 CABG were performed during the follow-up period. The overall 5 year freedom from reintervention rate was 82.4 $\pm$ 8.5%. Aortic regurgitation less than grade 1 had developed postoperatively in 4 patients and one patient showed progression of preexisting aortic regurgitation from grade II to III. Conclusion: Patch angioplasty in left main coronary ostial lesion showed acceptable short-term and long-term results in this study. However, restenosis at the patch anastomosis site and aortic regurgitation should be carefully investigated during the follow-up period.

배경: 좌주관상동맥 개구부 협착에서의 혈관성형술은 기존의 관상동맥우회술 시행 시에 발생할 수 있는 혈류 경합과 역행성 혈류의 문제를 해결할 수 있는 방법으로 여겨지고 있다. 본 연구에서는 좌주관상동맥 혈관성형술의 수술 성적과 예후에 대한 분석을 시행하여 좌주관상동맥 혈관성형술의 수술적 효용성을 확인하고자 하였다. 대상 및 방법: 1991년 7월부터 2003년 5월까지 부천세종병원에서 좌관상동맥 개구부 협착으로 혈관성형술을 시행 받은 29명의 환자들을 대상으로 환자들의 수술 전 임상양상, 수술결과, 수술 후 관상동맥조영술과 심초음파 검사 등을 후향적으로 분석하였다. 대상 환자들의 평균나이는 53.1$\pm$12.5세였으며 남녀비는 8 : 21이었다. 여성 환자 중 12예에서는 뚜렷한 죽상 경화증의 위험인자를 확인할 수 없었다. 26예(89.7%)의 환자는 다른 원위부 관상동맥에 병변이 없는 단독 좌주관상동맥 개구부 협착 소견을 보였다. 결과: 28예의 환자에서 전방접근법을 사용하였고, 1예의 환자에서 상방접근법을 사용하였으며, 주폐동맥의 절단을 1예에서 시행하였다. 4예의 환자에서 관상동맥우회술을 동시에 시행하였다 수술 사망은 1예(3.4%)에서 발생하였으며 장기 추적관찰 결과 1예에서 외상으로 인한 만기 사망이 발생하여 5년 생존율은 91.2$\pm$6.1%였다. 수술 후 13예(44.8%)의 환자에서 17차례의 관상동맥조영술이 시행되었으며, 이 중 2예에서 첩포 원위부 협착이 발생하였고 1예에서 우관상동맥 개구부의 새로운 협착이 발생하여 3예의 경피적 중재술이 시행되었다. 1예의 환자에서 첩포 근위부 협착이 발생하여 관상동맥우회술을 시행하였다. 대상 환자들의 5년 재시술 회피율은 82.4$\pm$8.5%였다. 수술 후 1도 이하의 새로운 대동맥 폐쇄부전이 4예에서 그리고 수술 전 동반되었던 대동맥 폐쇄부전의 심화가 1예에서 관찰되었다. 결론: 본 연구에서 좌주관상동맥 혈관성형술은 좌주관상동맥 개구부의 협착에 사용될 수 있는 효과적인 수술방법임을 확인할 수 있었다. 그러나 수술 후 발생할 수 있는 혈관성형술 부위의 협착과 대동맥 폐쇄부전에 대한 면밀한 추적 관찰이 필요할 것으로 생각된다.

Keywords

References

  1. Am J Cardiol v.44 Atherosclerosis of the left main coronary artery: 5 year results of surgical treatment Loop,F.D.;Lytle,B.W.;Cosgrove,D.M.;Sheldon,W.C. https://doi.org/10.1016/0002-9149(79)90304-7
  2. J Thorac Cardiovasc Surg v.85 Angioplasty of the left main coronary artery for isolated left main coronary artery disease Hitchcock,J.F.;Robles de Merdina,E.O.;Jambroes,G.
  3. Eur J Cardiothorac Surg v.11 Surgical angioplasty of the left main coronary artery Dion,R,;Elias,B.;El Khoury,G.; Noirhomme,P.;Verhelst,R.;Hanet,C. https://doi.org/10.1016/S1010-7940(97)01181-0
  4. J Thorac Cardiovasc Surg v.113 Superior approach to the left main coronary artery for surgical angioplasty Eishi,K.;Sasaki,H.;Nakano,K.(et al.) https://doi.org/10.1016/S0022-5223(97)70379-9
  5. Ann Thorac Surg v.68 Arterial patch angioplasty for reconstruction of proximal coronary artery stenosis Liska,J.;Jnsson,A.;Lockowandt,U.;Herzfeld,I.;Gelinder,S.;Franco-Cereceda,A. https://doi.org/10.1016/S0003-4975(99)01124-8
  6. J Thorac Cardiovasc Surg v.98 Surgical repair of stenotic ostial lesions of the left main coronary artery Sullivan,J.;Murphy,D.
  7. Korean J Thorac Cardiovasc Surg v.31 The clinical experience of patch angioplasty in isolated main coronary artery stenosis Yoon,C.S.;Yoo,K.J.;Lee,K.J.;Kim,D.J.;Kang,M.S.
  8. Ann Thorac Surg v.62 Coronary ostial reconstruction Ridley,P.D.;Wisheart,J.D. https://doi.org/10.1016/0003-4975(96)00266-4
  9. Korean J Thorac Cardiovasc Surg v.32 Surgical angioplasty of the left main coronary artery stenosis Chung,S.H.;Yang,J.H.;Kim,K.B.;Ahn,H.
  10. Korean J Cardiovasc Surg v.34 The immediate and long term result of surgical angioplasty of left main and proximal left anterior descending coronary artery Ahn,H.S.;Kim,E.J.;Lee,W.Y.;Shin,Y.C.;Chee,H.K.;Choi,K.M.
  11. J Am Coll Cardiol v.7 Isolated coronary ostial stenosis in women thompson,R. https://doi.org/10.1016/S0735-1097(86)80217-0
  12. J Cardiovasc Surg v.26 The incidence and management of coronary ostial stenosis Hutter,J.A.;Pasaoglu,I,;Williams,B.T.
  13. Circulation v.91 Comparison of surgical and medical group survival in patients with left main coronary artery disease Caracciolo,E.A.;Davis,K.B.;Sopko,G.(et al.) https://doi.org/10.1161/01.CIR.91.9.2325
  14. Am Heart J v.116 Surgical revascularization of left main coronary artery stenosis: determinants of preoperative and long term outcome in the 1980s Gomberg,J.;Klien,L.W.;Seelaus,P.;Paar,G.V.;Agarwal,J.B.;Helfant,R.H.
  15. Ann Surg v.162 Coronary endarterectomy with patch graft reconstruction Effler,D.B.;Sones,F.M.;Favaloro,R.;Groves,L.K. https://doi.org/10.1097/00000658-196510000-00005
  16. Arch Surg v.91 Proximal endarterectomy: arterial reconstruction for coronary occlusion at aortic origin Sabiston,D.C.;Ebert,P.A.;Friesinger,G.C.;Ross,R.S.Sinclair-Smith,B. https://doi.org/10.1001/archsurg.1965.01320170052008
  17. J Thorac Cardiovasc Surg v.60 Severe segmental obstruction of the left main coronary and its division: surgical treatment by the saphenous vein graft technique Favaloro,R.G.;Effler,D.B.;Groves,L.K.;Sheldon,W.C.;Shirey,E.K.;Sones,F.M.
  18. Ann Thorac Surg v.58 Left main coronary reconstruction after radiation therapy Gaudiani,V.A.;Siegel,S.B.;McIntosh-Yellin,N.L. https://doi.org/10.1016/0003-4975(94)92263-2
  19. Surg Clin North Am v.50 Acute coronary insufficiency and life threatening cardiac arrhythmias eight months after triple heart valve replacement Najafi,H.;Escamilla,H.A.;Clark,J.G. https://doi.org/10.1016/S0039-6109(16)39250-7
  20. Thorac Cardiovasc Surg v.43 Idiopathic isolated coronary astial stenosis: a rare lesion with particular clinical and surgical implications Panza,A.;Masiello,P.;Iesu,S.;Triumbari,F.;Gigantino,A.;Di Leo,L.;DiBenedetto,G. https://doi.org/10.1055/s-2007-1013766
  21. Eur J Cardiothorac Surg v.20 Direct ostioplasty of the left main coronary artery using the right internal thoracic artery as patch material Nagy,Z.L.;Szokol,M.;Peterffy,A. https://doi.org/10.1016/S1010-7940(01)00992-7
  22. Ann Thorac Surg v.65 Left main coronary artery patch angioplasty; Midterm experience and follow-up with spiral computed tomography Meseguer,J.;Hurle,A.;Fernandez-Latorre,F.;Alonso,S.;Llamas,P.;Casillas,J.A. https://doi.org/10.1016/S0003-4975(98)00265-3
  23. Thorac Cardiovasc Surg v.44 Surgical patch ostiumplasty of the left main coronary artery Schmuziger,M.;Christenson,J.T.
  24. Eur J Cardiothorac Surg v.23 Transesophageal echocardiography evaluation and follow-up of left main coronary artery patch angioplasty Sharoni,E.;Erez,E.;Shapira,Y.;Vidne,B.;Sagie,A. https://doi.org/10.1016/S1010-7940(02)00799-6
  25. Int Cardiac Imag v.9 no.Suppl 1 The role of magnetic resonance in the evaluation of functional results afer CABG/PTCA Van Rossum,A.C.;Gajee,M.A.;Doesburg,T.;Hofman,M.;Valk,J. https://doi.org/10.1007/BF01143147