한국어병학회지 (Journal of fish pathology)

  • 제17권3호
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  • Pages.217-222
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  • 2004
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  • 1226-0819(pISSN)
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  • 2233-5412(eISSN)
한국어병학회 (The Korean Society of Fish Pathology)
권호 표지

양식산 넙치, Paralichthys olivaceus 식세포의 식작용 활성에 미치는 chloramphenicol의 영향

Effects of chloramphenicol on chemiluminescence response of leukocytes isolated from olive flounder, Paralichthys olivaceus

  • 발행 : 2004.12.30
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초록

This study was performed to investigate the immunological side effects of chloramphenicol (CAP) on olive flounder, Paralichthys olivaceus. To investigate immunological effects on olive flounder, we determined the changes of chemiluminescence (CL) response of flounder kidney-derived leucocyte after the treatment of CAP in vivo and in vitro. The CL activity was significantly decreased in a dose-dependent manner during the treatment of CAP in vitro. Similarly, a dose-dependent reduction of CL response, although not significant, were observed during the treatment of CAP in vivo. The results suggest that CAP reduced the function of flounder phagocytosis in vivo and in vitro, indicating the immunosuppressive ability of CAP.

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참고문헌

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