Journal of Gastric Cancer
- 제4권3호
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- Pages.169-175
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- 2004
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- 2093-582X(pISSN)
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- 2093-5641(eISSN)
위암 환자에서 p53과 HSP27의 임상병리학적 의의
Clinicopathological Significance of p53 and HSP27 in Gastric-cancer Patients
- Lee, Ha-Gyoon (Departments of Surgery College of Medicine, Hanyang University) ;
- Kwon, Sung-Joon (Departments of Surgery College of Medicine, Hanyang University) ;
- Baek, Seung-Sam (Departments of Pathology, College of Medicine, Hanyang University)
- 발행 : 2004.09.01
초록
Purpose: The tumor suppressor gene p53 has been shown to be a factor in the carcinogenesis or progression of gastric cancer. The mutant p53 has been reported to cause a higher risk of lymph-node metastasis. Futhermore, mutation of the p53 has been linked to a poor prognosis for gastric cancer. The heat shock protein-27 (HSP27), a stress protein, has also been reported to be a poor prognostic factor in ovarian and breast cancers. However, in gastric-cancer patients, controversies exist as to its influence on the prognosis. In the present study, we used an immunohistochemical stain to observe the effects of p53 and HSP27 on the clinicopathological factors and on the prognosis for gastric-cancer patients. Materials and Methods: To evaluate the significance of p53 and HSP27 in gastric cancer patients, we analyzed 212 cases of gastric cancer (stage I.IV). Tissue samples of 212 patients were stained immunohistochemically for the mutant p53 protein and for HSP27. The correlations between protein expression and the clinicopathological factors were investigated. Results: The overall expression rates for p53 and HSP27 were