Journal of Gastric Cancer
- 제4권3호
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- Pages.156-163
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- 2004
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- 2093-582X(pISSN)
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- 2093-5641(eISSN)
위암에서 조직학적 특징에 따른 혈청 E-cadherin의 농도
Concentration of E-cadherin Correlated with Pathologic Features in Gastric Cancer
- 허훈 (가톨릭대학교 의과대학 외과학교실) ;
- 송교영 (가톨릭대학교 의과대학 외과학교실) ;
- 김진조 (가톨릭대학교 의과대학 외과학교실) ;
- 진형민 (가톨릭대학교 의과대학 외과학교실) ;
- 김욱 (가톨릭대학교 의과대학 외과학교실) ;
- 박조현 (가톨릭대학교 의과대학 외과학교실) ;
- 박승만 (가톨릭대학교 의과대학 외과학교실) ;
- 임근우 (가톨릭대학교 의과대학 외과학교실) ;
- 박우배 (가톨릭대학교 의과대학 외과학교실) ;
- 김승남 (가톨릭대학교 의과대학 외과학교실) ;
- 전해명 (가톨릭대학교 의과대학 외과학교실)
- Hur, Hoon (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Song-Gyo-Young (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Kim, Jin-Jo (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Chin-Hyung-Min (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Kim, Wook (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Park, Cho-Hyun (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Park, Seung-Man (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Lim-Keun-Woo (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Park, Woo-Bae (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Kim, Seung-Nam (Department of Surgery, College of Medicine, The Catholic University of Korea) ;
- Jeon, Hae-Myoung (Department of Surgery, College of Medicine, The Catholic University of Korea)
- 발행 : 2004.09.01
초록
Purpose: While E-cadherin in normal cells induces calciumdependent cell-cell adhesion, in malignant cell, it plays a role in invasion and metastasis with a reduction of adhesion. Serum soluble E-cadherin is a result of the reduction of the cellular E-cadherin molecule and is found in the circulation of normal individuals, but it is particularly known to be increased in patients with malignancies. Accordingly, through checking the level of serum soluble E-cadherin in patients with gastric cancer and analyzing it in the view of clinicopathology, we investigated whether serum soluble E-cadherin could be translated into a clinicopathologic esult and used as a tumor marker. Materials and Methods: The investigation targeted 88 patients who had been diagnosed as having gastric cancer by the Department of Surgery, St. Mary's Hospital, from October 1, 2002, to July 30, 2003, and who had under gone performed surgery. We measured the level of preoperative serum E-cadherin in the 88 patients by unsing ELISA. Among them, we collected gastric cancer tissues from 54 patients and executed immunohistochemistry for E-cadherin. The samples were compared with normal tissues in terms of both serum E-cadherin level and immunohistochemistry level, as well as with other clinicopathologic factors. Result: The mean serum E-cadherin level of the 88 patients was 4368.7 ng/ml and was significantly higher than the level in 12 normal control patients, 3335.5 ng/ml (P=0.016). In terms of clinicopathology, the serum level of E-cadherin was significantly correlated with increasing age (P=0.0006) and was higher in positive venous invasion patients (P=0.0005). When the E-cadherin immunohistochemical stain was compared with the serum E-cadherin level in 54 patients, no significant statistically meaningful result was obtained (P=0.2881). However, 4 patients with serum E-cadherin levels about 6000 ng/ml were classified into the lower expression group (