대한치과교정학회지 (The korean journal of orthodontics)

  • 제34권2호
  • /
  • Pages.131-142
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  • 2004
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  • 2234-7518(pISSN)
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  • 2005-372X(eISSN)
대한치과교정학회 (The Korean Association Of Orthodontists)
권호 표지

골절단을 이용한 급속 치아이동 후 치수 및 치주조직 변화

Tissue changes of pulp and periodontium on rapid tooth movement with osteotomy in dogs

  • 강경화 (원광대학교 치과대학 교정학교실) ;
  • 김은철 (원광대학교 치과대학 병리학교실) ;
  • 이선경 (원광대학교 치과대학 병리학교실) ;
  • 임채웅 (전북대학교 수의과대학 병리학교실) ;
  • 마쓰다 기꾸 (전북대학교 수의과대학 병리학교실) ;
  • 태기출 (원광대학교 치과대학 교정학교실) ;
  • 김상철 (원광대학교 치과대학 교정학교실)
  • Kang, Kyung-Hwa (Department of Orthodontics, School of Dentistry, Wonkwang University) ;
  • Kim, Eun-Cheol (Department of Oral Pathology School of Dentistry, Wonkwang University) ;
  • Lee, Sun-Kyung (Department of Oral Pathology School of Dentistry, Wonkwang University) ;
  • Lim, Chae-Woong (Department of Pathology School of Veterinary Medicine, Chonbuk National University) ;
  • Matduda, Kiku (Department of Pathology School of Veterinary Medicine, Chonbuk National University) ;
  • Tae, Ki-Chul (Department of Orthodontics, School of Dentistry, Wonkwang University) ;
  • Kim, Sang-Cheol (Department of Orthodontics, School of Dentistry, Wonkwang University)
  • 발행 : 2004.04.01
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초록

본 연구는 골절단을 이용한 치아-치조골 분절의 급속 치아이동 후 치수, 치주인대 및 치조골의 변화를 유성견에서 평가하고자 하였다. 하악 제4소구치의 근심, 원심, 치근단 부위에서 피질골을 절단하여 치아-골 분절을 형성하고 하악 제3소구치를 발거하면서 협측, 설측 부위의 피질골을 삭제하였다. 1주 휴지기 부여에 따라 휴지기군과 비휴지기군으로 나누어 치아의존형 견인장치로 6일 동안 견인하고 강화기를 거친 후 0주, 1주, 2주, 4주, 6주, 8주에 희생시켜 치수 치주인대 및 치조골의 조직 변화를 임상적, 방사선적, 조직학적 및 면역화학적으로 평가하여 다음과 같은 결과를 얻었다. 1 치아이동 양과 강화기 동안의 조직 치유 양상에서 휴지기 유무에 따른 차이는 없었다. 2. 견인측에서 골형성은 강화기 8주까지 계속되었는데 강화기 1-2주에 가장 활발하였으며 6-8주간의 변화는 적었다. 3. 비휴지기군의 강화기 1주에서 치조골 흡수 및 파골세포 출현, 염증세포 침윤이 가장 많았으며, 특징적으로 파상아세포가 압박측의 치주인대와 치수 내에 나타났다. 4. $TGF-\beta$는 치조골의 골기질 및 골모세포, 파골세포, 치수 내 파상아세포에서 강양성 발현을 보인 반면 치수, 백악모세포, 무세포성 백악질에서 경미한 양성 발현을 나타내는 부위 특이성이 있었다. 5. $TGF-\beta$는 견인측 치주인대의 치조골에 인접한 혈관 및 치주인대세포, 골모세포에서 강화기 초기 1-2주에 주로 발현되었으며 6주 이후에는 발현이 크게 감소하였다.

The movement of tooth-bone segments by osteotomy can simultaneously shift tooth and surrounding alveolar bone in a relatively short period. The purpose of this study was to evaluate the tissue changes in pulp, periodontal ligament, and alveolar bone in rapid tooth-bone movement with osteotomy. The mandibular 3rd premolar of a dog was extracted and cortical bones of the buccal and lingual area were eliminated, and then cortical bones around the mesial and distal area of root, and below the root apex of the mandibular 4th premolar were osteotomized. After a one-week latency period, a tooth-borne distraction device was activated for 6 days. And pulp, periodontal ligament and alveolar bone were evaluated clinically, radiologically, histologically and immunohistochemically at 0, 1, 2, 4, 6, 8 weeks of the consolidation Period and conclusions were roached as follows. 1. Latency period didn't affect total amount or tooth movement and healing process of tissue during consolidation period. 2. Bone formation continued through 8 weeks of consolidation in distracted side, with a high peak at 1-2 weeks, and the lowest at 6-8 weeks or consolidation. 3. At 1 week of consolidation, alveolar bone resorption, osteoclast appearance and inflammatory cell infiltration were the most active, and dentinoclasts characteristically appeared on the pulp and pressure side of the periodontal ligament. 4. The expression of $TGF-\beta$ was area-specific, as it was strong-positive at bone matrix, osteoblast osteoclast of alveolar bone, and dentinoclast inside pulp, but weak in pulp, cementoblast and acellular cementum. 5. The expression of $TGF-\beta$ was generally observed at the initial 1-2 weeks of consolidation at vessels, periodontal ligament cells, and osteoblast near alveolar bone on the distraction side of the periodontal ligament, and was significantly decreased after 6 weeks of consolidation.

키워드

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