Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 14 Issue 1
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- Pages.11-23
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- 2004
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Efficacy and Safety of Cyclosporine Therapy in Children with Nephrotic Syndrome
소아 신증후군에서의 Cycplosporine의 치료효과 및 안전성
- Chon, Myoung-Hun (Division of Pharmaceutical Services, Samsung Medical Center) ;
- Lee, Suk-Hyang (Graduate School of Clinical Pharmacy, Sookmyung Women's University) ;
- Jin, Dong-Kyu (Department of Pediatrics, Samsung Medical Center) ;
- Sohn, Kie-Ho (Division of Pharmaceutical Services, Samsung Medical Center) ;
- Choi, Kyung-Eob (Division of Pharmaceutical Services, Samsung Medical Center)
- Published : 2004.06.01
Abstract
Although most children with idiopathic nephrotic syndrome respond to corticosteroid therapy, many responders show steroid dependency and frequent relapse. In these children, one of the major problems is the serious side effects resulting from continuous steroid therapy. Thus, this study was conducted to assess the therapeutic efficacy and safety of six-month cyclosporine treatment with the low-dose deflazacort therapy in children with nephrotic syndrome. Thirty children with steroid dependence (SD), frequent relapse (FR) and steroid resistance (SR) were enrolled in this study. They were treated with 6-month oral cyclosporine