Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Regulatory Effect of Atopic Allergic Reaction by Modified Gagam-danguieumja

  • Na, Ho-Jeong (College of Oriental Pharmacy, Wonkwang University, College of Oriental Medicine, Kyung Hee University) ;
  • Kwon, Dong-Yeul (College of Oriental Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University) ;
  • Park, Eun-Jeong (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Eun-Hee (Division of Beauty Arts, Jeonbuk Science College) ;
  • Hong, Seung-Heon (College of Oriental Pharmacy, Wonkwang University)
  • Published : 2004.12.01
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Abstract

Gagam-danguiemja (GDGJ), a traditional Korean prescription, has been used as therapeutics for atopic allergic diseases such as atopic dermatitis. To evaluate the atopic allergic effect of modified GDGJ, we investigated a possible effect of GDGJ on mast cell-mediated allergic reaction, cytokinases secretion and mRNA expression in vivo and in vitro. Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered by GDGJ (0.01, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear oedema was significantly reduced. TNF-${\alpha}$, IL-8, and IL-6 secretion were inhibited by GDGJ in the human mast cell line (HNC-1). But TNF-${\alpha}$, IL-8, and IL-6 mRNA expression were not inhibited by GDGJ at the dose of 0.01 mg/ml. These findings may help in understanding the mechanism of action of this herbal medication, leading to the control of mast cells in atopic allergic reaction like AD.

Keywords

References

  1. Ackermann, L., Harvima, I.T. (1998) Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-a and their degranulation is associated with expression of ICAMI in the epidermis. Arch. Dermatol. Res. 290, 353-359 https://doi.org/10.1007/s004030050317
  2. Allansmith, M.R., Baird, R.S., Ross, R.N., Barney, N.P., and Bloch, K.J. (1989) Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study. Acta Ophthalmol. 192, 145-153
  3. Baggiolini, M., Dewald, B., and Moser, B. (1994) Interleukin 8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55, 97-179
  4. Bittlemann, D., and Casale, T. (1994) Allergic models and cytokines. Am. J. Respir. Crit. Care Med. 150, 72-76 https://doi.org/10.1164/ajrccm.150.1.8025776
  5. Bradding, P., Feather,IH., Wilson, S., Bardin, P.G., Heusser, C.H., Holgate, ST, and Howarth, P.H. (1993) Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitis subjects: the mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J. Immunol. 151, 3853-3865
  6. Euber, K., Hilger, R. A., and Konig, W. (1991) Interleukin-3, interleukin-8, fMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis. Immunology. 73, 83-87
  7. Galli, S.J. (1993) New concept about the mast cell. N. Engl. J. Med. 328, 257-265 https://doi.org/10.1056/NEJM199301283280408
  8. Gordon, J.R, Burd, P.R, and Galli, S.J. (1990) Mast cells as a source of multifunctional cytokines. Immunol. Today 11, 458-464 https://doi.org/10.1016/0167-5699(90)90176-A
  9. Groves, R.W., Allen, M.H., Ross, E.L., Barker, J.N., Mac, and Donald, W.N. (1995) Tumor necrosis factor alpha is proinflammatory in normal human skin and modulates cutaneous adhesion molecule ecpression. Br. J. Dermatol. 132, 345-352 https://doi.org/10.1111/j.1365-2133.1995.tb08666.x
  10. Guo, Y., Mochizuki, T., Morii, E., Kitamura, Y, and Maeyama, K. (1997) Role of mast cell histamine in the formation of rat paw edema. A microdialysis study. Eur. J. Pharmacol. 331, 237-243 https://doi.org/10.1016/S0014-2999(97)01002-9
  11. Kapp, A., Textor, A., Krutmann, J., and Moller, A. (1990) Immunomodulating cytokines in atopic dermatitis and psoriasis: Production of tumor necrosis factor and lymphotoxin by mononuclear cells in vitro. Br. J. Dermatol. 122, 587-592 https://doi.org/10.1111/j.1365-2133.1990.tb07279.x
  12. Kawabata, A., Kuroda, R., Kataoka, T., and Taneda, M. (1998) Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw. Br. J. Pharmacol. 125,419-422 https://doi.org/10.1038/sj.bjp.0702063
  13. Kim, H.M. (2000) Antiallergy drugs from Oriental medicines. Int. J. Orienta.l Med. 1, 1-7
  14. Kim, H.M., Yi, J.M., and Lim, K.S. (1999) Magnoliae flos inhibits mast cell-dependent immediate-type allergic reactions. Pharmacol. Res. 39, 107-111 https://doi.org/10.1006/phrs.1998.0414
  15. Kim, H.M., and Yang, D.J. (1999) Effect of Kumhwang-San on anaphylactic reaction in a murine model. Immunophar.ml. Immunotoxicol. 21, 163-174 https://doi.org/10.3109/08923979909016401
  16. Kitamura Y. (1989) Heterogeneity of mast cells and phenotypic changes between mast cell subpopulations. Annu. Rev. Immunol. 7, 59-76 https://doi.org/10.1146/annurev.iy.07.040189.000423
  17. Kobayashi, H., Ishizuka, T., and Okayama, Y. (2000) Human mast cells and basophils as sources of cytokines. Clin. Allergy Immunol. 17, 101-139
  18. Lentsch, A.B., and Ward, P.A, (2000). Regulation of inflammatory vascular damage. J. Pathol. 190, 343-348 https://doi.org/10.1002/(SICI)1096-9896(200002)190:3<343::AID-PATH522>3.0.CO;2-M
  19. Lippert, U., Hoer, A., Moller, A., Ramboer, I., Cremer, B., and Henz, B. M. (1998) Role of antigen induced cytokine release in atopic pruritus. Int. Arch. Allergy Immunol. 116,36-39 https://doi.org/10.1159/000023922
  20. Mannel, D.N., and Echtenacher, B. (2000) TNF in the inflammatory response. Chem. Immunol. 74, 141-161
  21. Maurer, M., Paus, R., and Czarnetzki, B.M. (1995) Mast cells as modulators of hair follicle cycling. Exp. Der.matol. 4,266-271
  22. McHugh, S.M., Wilson, A.B., Deighton, J., Lachmann, PJ., and Ewan, P.W. (1994)The profiles of interleukin (IL)-2,. IL-6, and interferon-gamma production by peripheral blood mononuclear cells from house-dust-mite-allergic patients: A role for IL-6 in allergic disease. Allergy 49, 751-759 https://doi.org/10.1111/j.1398-9995.1994.tb02098.x
  23. Moller, A., and Czarnetzki, B.M. (1993) Epidermal cytokines and mast cells. In: Epidermal growth factors and cytokines (eds Luger T. & Schwarz T.), Marcel Dekker Inc, New York, 377
  24. Moller, A, Henz, B.M., Grutzkau, A, Lippert, U, Aragane, Y, Schwarz, T, and Kruger-Krasagakes, S. (1998) Comparative cytokine gene expression: regulation and release by human mast cells. Immunology 93, 289-295 https://doi.org/10.1046/j.1365-2567.1998.00425.x
  25. Moller, A., Lippert, D., Le ann, D., Lessmann, D., Kolde, G., Hamann, K., Welker, P, Schadendorf, D., Rosenbach, T., Luger, T., and Czarnetzki, B,M. (1993) Human mast cells produce IL-8. J. Immunol. 151,3261-3266
  26. Mousli, M.C., Bronner, C., Bockaert, J., Rouot, B., Landry, Y (1990) Interaction of substance P, compound 48/80 and mastoparan with -subunit C-terminal of G protein. Immunol. Leu. 25, 355-357 https://doi.org/10.1016/0165-2478(90)90207-7
  27. Neuber, K., Hilger, R A., and Konig W. (1991) Interleukin-3, interleukin-8, fMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis. Immunology 73, 83-87
  28. Neuber, K., Steinbrucke, K., Kowalzik, L., Kohler, I., and Ring, J. (1995) Cytokine-mediated effects of peripheral blood mononuclear cells from patients in a new coculture system. Br. J. Dermatol. 133, 750-756 https://doi.org/10.1111/j.1365-2133.1995.tb02750.x
  29. Nilsson, G., Svensson, V., and Nilsson K. (1995) Constitutive and inducible cytokines mRNA expression in the human mast cell line HMC-l. Scand J. Immunol. 42, 76-81 https://doi.org/10.1111/j.1365-3083.1995.tb03628.x
  30. Osborn, L., Hession, C., Tizard, R., Vassalo, C., Luhowsky, S., Chi, Rosso. G, and Lobb, R. (1989) Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59,1203-1211 https://doi.org/10.1016/0092-8674(89)90775-7
  31. Plaut, M., Pierce, J.H., Watson, C.J., Hanley-Hyde J., Nordan, RP., and Paul WE., (1989) Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or calcium ionophores. Nature 339, 64-67 https://doi.org/10.1038/339064a0
  32. Pober, J.S., Gimbrone, M.A., Lapierre, L.A., Mendrick, D.L., Fiers, W., Rothlein, R., and Springer, T.A. (1986) Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J.lmmunol. 137, 1893-1896
  33. Soter, N.A. (1989) Morphology of atopic eczema. Allergy 44 (Suppl.9),16-19 https://doi.org/10.1111/j.1398-9995.1989.tb02449.x
  34. Sumito, S., Kawai, M., Kasajirna, Y., and Hamamoto T. (1992) Increased plasma tumor necrosis factor-alpha concentration in atopic dermatitis. Arch. Dis. Child 67, 277-279 https://doi.org/10.1136/adc.67.3.277
  35. Van, Joost. T., Kozel, M.M.A., Tank, B., Troost, R., and Prens, E.P. (1992) Cyclosporin in atopic dermatitis. Modulation in the expression of immunological markers in lesional skin. J. Am. Acad. Dermatol. 27, 922-928 https://doi.org/10.1016/0190-9622(92)70288-Q
  36. Vergnolle, N., Hollenberg, M.D., Sharkey, K.A., and Wallace, J.L. (1999) Characterization of the inflammatory response to proteinases activated receptor-2 (PAR-2)-activating peptides in the rat paw. Br. J. Pharmacol. 127, 1083-1090 https://doi.org/10.1038/sj.bjp.0702634
  37. Walsh, L.J., Trinchiery, G., Waldorf, H.A., Whitaker, D., and Murphy, G.F. (1991) Human dermal mast cells contain and release tumor necrosis factor, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. USA 88, 4220-4224 https://doi.org/10.1073/pnas.88.10.4220
  38. White, M. (1999) Mediators of inflammation and the inflammatory process. J. Allergy Clin. Immunol. 103, 5378-5381