Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

Regulatory Effect of Th-2 Cytokine Production in Mast Cells by 02PS15

  • Na, Ho-Jeong (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, College or Oriental Pharmacy, Wonkwang University) ;
  • Seo, Young-Wan (Division of Ocean Science, Korea Maritime University) ;
  • Lee, Eun-Hee (Division of Beauty Arts, Jeonbuk Science College) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College or Oriental Pharmacy, Wonkwang University)
  • Published : 2004.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

02PS15 extracts (BuOH, $H_2O$, and crude extracts) significantly inhibited IL-4 and IL-6 secretion from the phytohemagglutinin (PHA)-plus phorbol 12-myristate 13-acetate (PMA)-induced peripheral blood mononuclear cleas (P<0.05). 02PS15 extracts (BuOH and crude extracts) also significantly inhibited the histamine release from rat peritoneal mast cells (P<0.05). Significant reduced levels (P<0.05) of PMA- and A23187-induced IL-8 were observed in the human mast cell line, HMC-1, with O2PS15 extracts (BuOH and crude extracts). 02PS15 extracts (BuOH and crude extract) downregulated the expression of IL-6 and IL-8 in the activated HMC-1. These results suggest that O2PS15 has the inhibitory effect of atopic allergic reaction anil this might be useful for clinical application to treat several allergic diseases such as atopic dermatitis.

Keywords

References

  1. Abbas, A. K., Murphy, K. M. and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793 https://doi.org/10.1038/383787a0
  2. Allansmith, M. R, Baird, R. S., Ross, R. N., Barney, N. P. and Bloch, K. J. (1989). Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study. Acta. Ophthnlmol. 192, 145-153
  3. Baggiolini, M., Dewald, B. and Moser, B. (1994). Interleukin 8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55, 97-179
  4. Bradding, P, Feather, I. H., Howarth, P. H., Mueller, R, Roberts, J. A., Britten, K., Bews, J. P., Hunt, T. C., Okayama, Y. and Heusser, C. H. (1992). Interleukin 4 is localized to and released by human mast cells. J. Exp. Med. 176, 1381-1386 https://doi.org/10.1084/jem.176.5.1381
  5. Cooper, K. D. (1994). Atopic dermatitis: recent trends in pathogenesis and therapy. J. Invest. Dermatol. 102, 128-137 https://doi.org/10.1111/1523-1747.ep12371746
  6. Euber, K., Hilger, R.A. and Konig, W. (1991). Interleukin-3, interleukin-8, fMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis. Immunology 73, 83-87
  7. Galli, S. J. (1993). New concepts about the mast cell. N. Engl. J. Med. 328, 257-265 https://doi.org/10.1056/NEJM199301283280408
  8. Gordon, J. R., Burd, P. R. and Galli, S. J. (1990). Mast cells as a source of multi-functional cytokines. Immunol. Today 11, 458-464
  9. Hopkin, J. M. (1998). Mechanisms of enhanced prevalence of asthma and atopy in developed countries. Allergy 14, 75-79
  10. Kim, H. M. (2000). Antiallergy drugs from Oriental medicines. Int. J. Orient. Med. 1, 1-7
  11. Kim, H. M. and Cho, S. H. (1999). Lavender Oil inhibits immediate-type allergic reaction in mice and rats. J. Pharm. Pharmacal. 51, 221-226 https://doi.org/10.1211/0022357991772178
  12. Kim, H. M., Yi, J. M. and Lim, K. S. (1999). Magnoliae flos inhibits mast cell-dependent immediate-type allergic reactions. Pharmacol. Res. 39, 107-111
  13. Leung, D. Y. M. (2000). Atopic dermatitis: new insights and opportunities for therapeutic intervation. J. All. Clin. Immunol. 105, 860-876 https://doi.org/10.1067/mai.2000.106484
  14. McHugh, S. M., Wilson, A. B., Deighton, J., Lachmann, P. J. and Ewan, P W. (1994). The profiles of interleukin IL-2, IL-6, and interferon-gamma production by peripheral blood mononuclear cells from house-dust-mite-allergic patients: A role for IL-6 in allergic disease. Allergy 49, 751-759 https://doi.org/10.1111/j.1398-9995.1994.tb02098.x
  15. Moller, A., Henz, B.M., Grutzkau, A., Lippert, U., Aragane, Y., Schwarz, T. and Kruger-Krasagakes, S. (1998). Comparative cytokine gene expression: regulation and release by human mast cells. Immunology. 93, 289-95 https://doi.org/10.1046/j.1365-2567.1998.00425.x
  16. Na, H. J., Jeong, H. J., Bae, H., Kim, Y. B., Park, S. T., Yun, Y G. and Kim, H. M. (2002). Tongkyutang inhibits mast cell dependent allergic reactions and inflammatory cytokines secretion. Clinica Chimica Acta 319, 35-41 https://doi.org/10.1016/S0009-8981(02)00011-6
  17. Neuber, K., Steinbrucke, K., Kowalzik, L., Kohler, I. and Ring, J. (1995). Cytokine-mediated effects of peripheral blood mononuclear cells from patients in a new coculture system. Br. J. Dermatol. 133, 750-756 https://doi.org/10.1111/j.1365-2133.1995.tb02750.x
  18. Olsson, N., Taub, D. D. and Nilsson, G. (2004). Regulation of Mast Cell Migration by TH1 and TH2 Cytokines: Identification of Tumour Necrosis Factor-a and Interleukin4 as Mast Cell Chemotaxins. Scand. J. Immunol. 59(3), 267-272 https://doi.org/10.1111/j.0300-9475.2004.01397.x
  19. Plaut, M., Pierce, J. H., Watson, C. J., Nordan, R. P. and Paul, W. E. (1989). Mast cell lines produce lymphokines in response to cross-linkage of FceRI or to calcium ionophores. Nature 339, 64-67 https://doi.org/10.1038/339064a0
  20. Romagnani, S., Parronchi, P., DElios, M. M., Romagnani, P., Annuziato, F, Piccinni, M. P., Manetti, R, Sampognaro, S., Mavilia, C., De Carli, M., Maggi, E. and Del Prete G. F (1997). An update on human Th-1 and Th-2 cells. Int. Arch. All. Immunol. 113, 153-156
  21. Rukwied, R., Lischetzki, G., McGlone, F., Heyer, G. and M. Schmelz. (2000). Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Br. J. Dermatol. fun. 142(6), 1114-1120 https://doi.org/10.1046/j.1365-2133.2000.03535.x
  22. Scudiero, D. A., Shoemaker, R.H., Paull, K.D., Monks, A., Tierney, S., Nofziger, T. H., Currens, M.J., Seniff, D. and Boyd, M. R. (1988). Evaluation of a soluble tetrazoliurnl formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48,4827-4833
  23. Shin, B. K., Lee, E. H. and Kim, H. M. (1997). Suppression of Lhistidine decarboxylase mRNA expression by methyleugenol. Biochem. Biophys. Res. Commun. 232, 188-191 https://doi.org/10.1006/bbrc.1997.6260
  24. Shore, P. A., Burkhalter, A. and Cohn, V. H. (1959). A method for fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127, 182-186
  25. Sosa Vazquez, M., Orea, M. and Flores, G. (2001). New concepts about atopic dermatitis. Rev. Alerg. Mex. 48, 15-24
  26. Taylor, M. L. and Metcalfe, D. D. (2001). Mast cells in allergy and host defense. Allergy Asthma Proc. 22, 115-119 https://doi.org/10.2500/108854101778148764
  27. Trefzer, D., Hofmann, M., Sterry, W. and Asadullah, K. (2003). Cytokine and anti-cytokine therapy in dermatology. Expert Opin. BioI. Ther. 3, 733-743 https://doi.org/10.1517/14712598.3.5.733
  28. Van Joost, T., Kozel, M. M. A., Tank, B., Troost, R and Prens, E. P. (1992). Cyclosporin in atopic dermatitis. Modulation in the expression of immunological markers in lesional skin. J. Am. Acad. Dermatol. 27, 922-928 https://doi.org/10.1016/0190-9622(92)70288-Q
  29. Yurt, R. W., Leid, R. W. and Austen, K. F. (1977). Native heparin from rat peritoneal mast cells. J. BioI. Chem. 252, 518-521