Biomolecules & Therapeutics

  • 제12권2호
  • /
  • Pages.79-84
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  • 2004
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

Regulatory Effect of Th-2 Cytokine Production in Mast Cells by 02PS15

  • Na, Ho-Jeong (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, College or Oriental Pharmacy, Wonkwang University) ;
  • Seo, Young-Wan (Division of Ocean Science, Korea Maritime University) ;
  • Lee, Eun-Hee (Division of Beauty Arts, Jeonbuk Science College) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College or Oriental Pharmacy, Wonkwang University)
  • 발행 : 2004.06.01
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초록

02PS15 extracts (BuOH, $H_2O$, and crude extracts) significantly inhibited IL-4 and IL-6 secretion from the phytohemagglutinin (PHA)-plus phorbol 12-myristate 13-acetate (PMA)-induced peripheral blood mononuclear cleas (P<0.05). 02PS15 extracts (BuOH and crude extracts) also significantly inhibited the histamine release from rat peritoneal mast cells (P<0.05). Significant reduced levels (P<0.05) of PMA- and A23187-induced IL-8 were observed in the human mast cell line, HMC-1, with O2PS15 extracts (BuOH and crude extracts). 02PS15 extracts (BuOH and crude extract) downregulated the expression of IL-6 and IL-8 in the activated HMC-1. These results suggest that O2PS15 has the inhibitory effect of atopic allergic reaction anil this might be useful for clinical application to treat several allergic diseases such as atopic dermatitis.

키워드

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