The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Bombycis corpus on Streptozotocin-induced Diabetic Rats

Streptozotocin으로 유발된 당뇨쥐에 대한 백강잠(白?蠶)의 혈당 및 당대사 효소활성에 관한 효과

  • Hyun, Min-Kyung (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Sin, Won-Yong (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Mi-Rang (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Hyeon-Cheol (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Yoon, Cheol-Ho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Byoung-Mu (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 현민경 (동국대학교 한의과 대학 내과학 교실) ;
  • 신원용 (동국대학교 한의과 대학 내과학 교실) ;
  • 김미랑 (동국대학교 한의과 대학 내과학 교실) ;
  • 신현철 (대구한의대학교 한의과 대학 내과학 교실) ;
  • 윤철호 (동국대학교 한의과 대학 내과학 교실) ;
  • 정지천 (동국대학교 한의과 대학 내과학 교실) ;
  • 정병무 (동국대학교 한의과 대학 내과학 교실)
  • Published : 2004.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This study was undertaken to investigate how Bombycis corpus (BC) effects the development and progress of complications occurring in Diabetes Mellitus (DM). Methods : Laboratory rats were seperated into three groups; normal, rats with DM and treated with BC, and rats with DM and not treated. In this study DM was experimentally induced through injection of streptozotocin. The BC treated group was given BC extract p.o. for 15 days. Then, The activities of glucose phosphatic enzymes and polyol pathway channels were observed. Results : The blood glucose level greatly increased in the DM groups after injection of streptoztocin, but it significantly decreased in the BC treated group. Significantly enhanced levels of serum insulin levels were seen in the BC treated group, while supressed levels were seen in the untreated DM group. Weight was recovered by the BC treated group, matching the normal group. Decreased enzyme activity of aldose reductase, sorbitol dehydrogenase and glucose-6-phosphatase were seen in BC treated diabetic rats. Increased enzyme activity, of the glucokinase and hexokinase were seen in BC treated diabetic rats. Conclusions : This study suggests that BC normalized the blood glucose and serum insulin levels destablized by DM. Because increased activity of glucose phosphatic enzymes, glucokinase and hexokinase, and decreased glucose-6-phosphatase activity, and suppression of polyol pathway enzymes, aldose reductase and sorbitol dehydrogenase, were all seen, these observations suggest that BC suppresses blood glucose levels and prevents complications due to DM.

Keywords

References

  1. 당뇨병학 대한당뇨병학회
  2. 당뇨병 v.1 no.1 우리나라 농촌 주민의 당뇨병에 관한 역학적 연구 김경식;최춘호;이도영;김응진
  3. 당뇨병 v.20 no.3 경기도 연천지역에서 당뇨병의 발생률 신찬수;김현규;김원배;박경수;김성연;조보연(등)
  4. 당뇨병 no.1 당뇨병의 합병증에 대한 고찰 이문규;정영환;원암우;이기업;최수봉
  5. Diabetes v.48 Role of oxidative stress in diabetic complications: a new perspective on an old paradigm Baynes, J.W.;Thorpe, S.R.
  6. Lancet v.2 Evidence for a food additive as a course of ketosis-prone diabetes Helgason, T.;jonasson, M.R.
  7. 동의신계내과학(하) 두호경
  8. 中醫治療內分泌代謝病 余永譜
  9. 醫部全錄 v.6 陳夢雷
  10. 丹溪心法 朱震亨
  11. 明淸名醫全書大成;李時珍醫學全書 柳長華(主編)
  12. 원색임상본초학 신민교
  13. 한국위생과학회지 v.6 no.1-2 Streptozotocin으로 유발된 당뇨쥐에 대한 백강잠의 영향 윤수홍;하헌
  14. 大韓韓醫學會誌 v.13 no.1 소絲, 白강蠶絲 및 原蠶蛾의 抗糖尿 作用에 關한 硏究 金亨奎;辛吉祚;曹基湖;金永錫;裵亨燮;李京燮
  15. 한국 영양학회지 v.31 no.2 고탄수화물 식이 섭취 마우스에서 상엽 및 누에 추출물의 혈당강하 효과 김미선;조여원;정성현;구성자
  16. 한국 영양학회지 v.31 no.7 인슐린 비의존형 (Type II) 당뇨환자에서 누에분말 섭취가 혈당 및 혈중지질농도에 미치는 영향 조미란;조여원;정성현;류재환
  17. 경희약대 논문집 v.24 누에와 혈당강하 활성 정성현;류정화;김은주;류강선
  18. 누에분말에 의한 Alloxan과 Streptozotocin 유발 고혈당 mouse의 혈당강하 효능에 관한 연구 이희삼
  19. 경희대한의대논문집 v.10 蠶이 alloxan 투여 家兎의 血糖量에 미치는 영향 權寧哲;金永錫;裵亨燮
  20. Glucokinase in liver, Methods in enzymology Walker, D.G.;Parry, M.J.;Bergmayer(ed.)
  21. J Biol Chem. v.184 no.2 Phosphatase of liver. I. Glucose-6-phosphatase Swanson, M.A.
  22. Diabetologia v.38 no.3 Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA Yamaoka, T.;Nishimura, C.;Yamashita, K.;Itakura, M.;Yamada, T.;Fujimoto, J.(et al.)
  23. Handbuch der physiol und path-chem. Analyse v.VIa Hollmann, S.;Hoppe-Seyler Thiefelder
  24. Clin Chim Acta. v.13 no.1 colorimetric glucose oxidase method for blood glucose Thompson, R.H.
  25. J Biol Chem. v.193 no.1 Protein measurement with folin phenol reagent Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J.
  26. 한국보건간호학회지 v.15 no.2 당뇨병 환자의 치료지시 이행군과 비이행군의 혈당과 만성 합병증 발생비교 송민선;유양숙;김희승
  27. 당뇨병의 합병증 v.22 강성구
  28. N Engl J Med. v.329 no.14 The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The Diabetes Control and Complications Trial Research Group
  29. British Medical Journal v.321 no.7258 Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study Stratton, I.M.;Adler, A.I.;Neil, H.A.;Matthews, D.R.(et al.)
  30. Arch Intern Med. v.132 no.4 Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature Schein, P.;Kahn, R.;Gorden, P.;Wells, S.;Devita, V.T.
  31. Diabetes Metab Rev. v.7 no.1 Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease Pugliese, G.;Tilton, R.G.;Williamson, J.R.
  32. J Clin Invest v.94 no.2 The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat Stevens, M.J.;Dananberg, J.;Feldman, E.L.;Lattimer, S.A.;Kamijo, M.;Thomas, T.P.(et al.)
  33. 동국한의학연구소논문집 v.7 no.1 腎臟組織에서 白?蠶 抽出物의 抗酸化 作用에 關한 硏究 이무형;윤철호;정지천