혈관경 전위를 이용한 선조작 골건막피판이 골 결손부 이식물에 미치는 영향과 적절한 혈관경 이식기간

The Effects of the Prefabricated Periosteofascial Flap through the Vascular Pedicles Transfer on the Bone Defect and the Optimal Period of the Pedicles Implantation

  • 원창훈 (고려대학교 의과대학 성형외과학교실) ;
  • 김상범 (고려대학교 의과대학 성형외과학교실) ;
  • 서성익 (고려대학교 의과대학 성형외과학교실) ;
  • 한승규 (고려대학교 의과대학 성형외과학교실) ;
  • 김우경 (고려대학교 의과대학 성형외과학교실) ;
  • 이병일 (고려대학교 의과대학 성형외과학교실)
  • Won, Chang-Hoon (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University) ;
  • Kim, Sang-Bum (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University) ;
  • Seo, Sung-Ik (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University) ;
  • Han, Seung-Kyu (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University) ;
  • Kim, Woo-Kyung (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University) ;
  • Lee, Byung-Il (Department of Plastic & Reconstructive Surgery College of Medicine, Korea University)
  • 발행 : 2004.10.29

초록

This study was designed to investigate the optimal period of pedicles implantation in the prefabricated periosteofascial flap with a vascular tissue transfer. The flap prefabrication was prepared with a transposition of left occipital pedicles on the calvarial fascia of male Sprague-Dawley rats. Thirty flaps were divided into five groups of six flaps, including control group (group I) of the conventional periosteofascial flap based on the lateral border of the rat calvarium. The prefabricated flap was elevated as an $1{\times}1cm$ sized island flap based on the implanted pedicle at 1, 2, 3, and 4 weeks after the pedicles transfer in groups II, III, IV, and V, respectively. After the completion of creating a critical-sized calvarial defect and implanting with hydroxyapatite granules, the flap was sutured back for covering the defect and kept isolated from surrounding tissues. Six weeks after flap repositioning, the osseous changes of the defect were examined with simple radiographic findings, radiodensitometric analysis, and histological studies. By simple radiographic findings, specimens of the control, groups IV and V showed homogeneous radioopacity within the defect. But in groups II and III, focal radiolucency was observed in the defect. In the radiodensitometric analysis, the control group and the group V showed significant increased radiodensites statistically. Histologically, the implanted hydroxyapatite was absorbed partly in the defect in groups II, III, and IV. In the defects of the control group and the group V, the implanted hydroxyapatite was kept in its volume and the deposition of the bone cells was observed sparsely. In conclusion, the prefabricated periosteofascial flap can be created with a vascular tissue transfer and the pedicles should be implanted at least for 4 weeks to bring out positive osseous changes in the calvarial defect.

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