Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE EXPERIMENTAL STUDY OF THE BONE REGENERATION ON ${\beta}$-TCP IN RABBIT CRANIAL BONE

가토 두개골에서 ${\beta}$-TCP와 자가골 이식에 관한 실험적 연구

  • Lee, Sung-Hoon (Division of Oral & Maxillofacial Surgery, College Of Medicine, Hanyang University) ;
  • Song, Seung-Il (Pundang Jesaeng Hospital) ;
  • Han, Ji-Young (Division of Oral & Maxillofacial Surgery, College Of Medicine, Hanyang University) ;
  • Hwang, Kyung-Gyun (Division of Oral & Maxillofacial Surgery, College Of Medicine, Hanyang University) ;
  • Paik, Sung-Sam (Department Of Dentistry, Department of Pathology, College Of Medicine, Hanyang University) ;
  • Shim, Kwang-Sup (Division of Oral & Maxillofacial Surgery, College Of Medicine, Hanyang University)
  • 이성훈 (한양대학교 의과대학 치과학교실 구강악안면외과) ;
  • 송승일 (분당제생병원) ;
  • 한지영 (한양대학교 의과대학 치과학교실 구강악안면외과) ;
  • 황경균 (한양대학교 의과대학 치과학교실 구강악안면외과) ;
  • 백승삼 (한양대학교 의과대학 치과학교실 병리학교실) ;
  • 심광섭 (한양대학교 의과대학 치과학교실 구강악안면외과)
  • Published : 2004.08.31
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Abstract

Pure-phase beta-tricalcium phosphate(${\beta}$-TCP) proved to be a bone regeneration material, providing the patient with vital bone at the defect site in a reasonable time, making a second surgical procedure for bone harvesting unnecessary. This study compares bone healing and BMP 2/4 expression in cranial defects in rabbits grafted with autogenous bone and ${\beta}$-TCP. Thirty New Zealand White rabbits was divided into 3 group of 10 animals each. Bilateral calvarial defects were made in the parietal bones of each animal. ${\beta}$-TCP placed in one defect and the other defects was filled with autogenous bone. The animal were sacrificed at 4, 8 and 12 weeks. Immunohistochemical analysis was used to investigate the expression of BMP 2/4. 1. The new bone formation around autogenous bone from 4 weeks and ${\beta}$-TCP from 8 weeks. 2. In autogenous bone graft, BMP 2/4 expression was decreased from 4 to 12 weeks. 3. In ${\beta}$-TCP graft, BMP 4 expression was increased from 8 to 12 weeks. But, BMP 2 was observed from 12 weeks. This study showed that bone healing, regeneration and, BMP 2/4 expression are delayed in grafted ${\beta}$-TCP than autogenous bone.

Keywords

References

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