치성상피종양으로부터 상악에 발생한 치성유령세포암종의 치험례

ODONTOGENIC GHOST CELL CARCINOMA ARISING FROM ODONTOGENIC EPITHELIAL TUMOR IN MAXILLA - A CASE REPORT

  • 김진학 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김문기 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김진 (연세대학교 치과대학 구강병리학교실, 구강종양연구소) ;
  • 김현실 (연세대학교 치과대학 구강병리학교실, 구강종양연구소) ;
  • 최희수 (국군수도병원 구강악안면외과) ;
  • 김형준 (연세대학교 치과대학 구강악안면외과학교실)
  • Kim, Jin-Hak (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Kim, Moon-Key (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Cha, In-Ho (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Kim, Jin (Dept. of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Hyun-Sil (Dept. of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University) ;
  • Choi, Hee-Soo (Dept. of Oral and Maxillofacial Surgery, The Armed Forced Capital Hospital) ;
  • Kim, Hyung-Jun (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
  • 발행 : 2004.06.30

초록

치성유령세포암종은 석회화치성낭종의 악성 부분으로 치성낭종, 치성종양 모두에서 기인할 수 있다. 다형성 상피 세포와 유령세포가 nucleated cell들과 혼재된 침윤성 종양의 형태로 나타나는 것이 특징이고, 국소 재발 및 원격 전이된 증례도 보고된 바있다. 저자들은 드문 치성종양인 치성유령세포암종을 상악골에서 경험하였기에 문헌 고찰과 함께 보고하였으며, 본 증례의 경우 향후 재발 및 전이 여부 파악을 위해 주기적인 경과 관찰이 필요하리라 사료된다. 또한 악성 변화의 요인으로 이종골 이식의 영향에 대한 연구도 필요하리라 사료된다.

The neoplastic variant of calcifying odontogenic cyst has various designation, and its malignant counterpart has been reported as aggressive epithelial ghost cell tumor or odontogenic ghost cell carcinoma. Odontogenic ghost cell carcinoma(OGCC) is a rare carcinoma first documented in 1985. It is composed of varying sized islands of anucleated cells with homogenous, pale eosinophilic cytoplasm, so called ghost cells, were admixed with nucleated cells. We report a case of maxillary OGCC developed from odontogenic epithelial tumor in a 25-year-old man with literature review.

키워드

참고문헌

  1. Ikemura K, Horie A, Tashiro H, et al. : Simultaneous occurrence of a calcifying odontogenic cyst and its malignant transformation. Cancer 1985;56:2861-2864 https://doi.org/10.1002/1097-0142(19851215)56:12<2861::AID-CNCR2820561224>3.0.CO;2-L
  2. Elzay RP : Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinoma. Oral Surg Oral Med Oral Pathol 1982;54:299-303 https://doi.org/10.1016/0030-4220(82)90099-8
  3. 유태민 : WHO 분류에 따른 치성종양의 임상 및 병리조직학적 연구. 연세대학교 대학원. 2003
  4. Fejerskov G, Krogh J : The calcifying ghost cell odontogenic tumor or the calcifying odontogenic cyst. J Oral Pathol 1972;1:273-287 https://doi.org/10.1111/j.1600-0714.1972.tb01666.x
  5. Praetorius F, Hjorting-Hansen E, Gorlin RJ, Vickers RA : Calcifying odontogenic cyst. Acta Odontol Scand 1981;39:227-240 https://doi.org/10.3109/00016358109162284
  6. Ellis GL, Shmookler BM : Aggressive (malignant?) epithelial odontogenic ghost cell tumor. Oral Surg Oral Med Oral Pathol 1986;61:471-478 https://doi.org/10.1016/0030-4220(86)90390-7
  7. Grodjesk JE, Dolinsky HB, Schneider, LC, et al. : Odontogenic ghost cell carcinoma. Oral Surg Oral Med Oral Pathol 1987;63:576-581 https://doi.org/10.1016/0030-4220(87)90231-3
  8. Scott J, Wood GD. Aggressive calcifying odontogenic cyst-a possible variant of ameloblastoma. Br J Oral Maxillofac Surg 1989;27:53-59 https://doi.org/10.1016/0266-4356(89)90127-7
  9. Kim J, Lee EH, Yook JI, et al. : Odontogenic ghost cell carcinoma: A case report with reference to the relation between apoptosis and ghost cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:630-635 https://doi.org/10.1067/moe.2000.109016
  10. McCoy BP, O’Carroll MK, Hall JM : Carcinoma arising in a dentinogenic ghost cell tumor. Oral Surg Oral Med Oral Pathol 1992;74:371-378 https://doi.org/10.1016/0030-4220(92)90078-5
  11. Siar CH, Ng KH : Aggressive (malignant?) epithelial odontogenic ghost cell tumour of the maxilla. J Laryngol Otol 1994;108:269-271
  12. Alcalde RE, Sasaki A, Misaki M, et al. : Odontogenic ghost cell carcinoma: Report of a case and review of the literature. J Oral Maxillofac Surg 1996;54:108-111 https://doi.org/10.1016/S0278-2391(96)90317-1
  13. Folpe AL, Tsue T, Rogerson L, et al. : Odontogenic ghost cell carcinoma: a case report with immunohistochemical and ultrastructural characterization. J Oral Pathol Med 1998;27:185-189 https://doi.org/10.1111/j.1600-0714.1998.tb01938.x
  14. Lu Y, Mock D, Takata T, et al. : Odontogenic ghost cell carcinoma; report of four new cases and review of the literature. J Oral Pathol Med 1999;28:323-329 https://doi.org/10.1111/j.1600-0714.1999.tb02048.x
  15. Kamijo R, Miyaoka K, Tachikawa T, et al. : Odontogenic ghost cell carcinoma: report of a case. J Oral Maxillofac Surg 1999;57:1266-1270 https://doi.org/10.1016/S0278-2391(99)90502-5