Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제30권3호
  • /
  • Pages.203-210
  • /
  • 2004
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

구강 편평태선 환자에서 steroid와 cyclosporine의 국소 도포 효과

THE EFFECT OF TOPICAL APPLICATION WITH STEROID AND CYCLOSPORINE ON ORAL LICHEN PLANUS PATIENTS

  • 홍순민 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 박성진 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 박지현 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 윤필영 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 명훈 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 고홍섭 (서울대학교 치과대학 구강내과진단학교실) ;
  • 정성창 (서울대학교 치과대학 구강내과진단학교실) ;
  • 이종호 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 김명진 (서울대학교 치과대학 구강악안면외과학교실)
  • Hong, Soon-Min (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Park, Sung-Jin (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Park, Jee-Hyun (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Yun, Pil-Young (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Myoung, Hoon (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Kho, Hong-Seop (Department of Oral Medicine and Oral Diagnosis, College of Dentistry, Seoul National University) ;
  • Chung, Sung-Chang (Department of Oral Medicine and Oral Diagnosis, College of Dentistry, Seoul National University) ;
  • Lee, Jong-Ho (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Kim, Myung-Jin (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University)
  • 발행 : 2004.06.30
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초록

The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.

키워드

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