Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제30권2호
  • /
  • Pages.143-149
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  • 2004
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

수술후 급성 동통에 대한 Tramadol/Acetaminophen과 Codeine/Acetaminophen/Ibuprofen의 효과 발현시점과 진통효과의 비교

COMPARISON OF TRAMADOL/ACETAMINOPHEN AND CODEINE/ACETAMINOPHEN/IBUPROFEN IN ONSET OF ANALGESIA AND ANALGESIC EFFICACY FOR POSTOPERATIVE ACUTE PAIN

  • 정영수 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김동기 (연세대학교 의과대학 의학통계학과) ;
  • 김문기 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 김형준 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 한무영 (연세대학교 의과대학 의학통계학과) ;
  • 이의웅 (연세대학교 치과대학 구강악안면외과학교실)
  • Jung, Young-Soo (Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Kim, Dong-Kee (Department of Biostatistics, College of Medicine, Yonsei University) ;
  • Kim, Moon-Key (Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Kim, Hyung-Jun (Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Cha, In-Ho (Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Han, Moo-Young (Department of Biostatistics, College of Medicine, Yonsei University) ;
  • Lee, Eui-Wung (Department of Oral and Maxillofacial Surgery, Oral Science Research Center, College of Dentistry, Yonsei University)
  • 발행 : 2004.04.30
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초록

Background: Some clinical trials have reported that a new analgesic combination of tramadol and acetaminophen provides good efficacy in various pain models. For the more clinical uses of this agent, comparisons about the onset of analgesia and analgesic efficacy in the acute state of pain with the other drugs known as strong analgesics were needed. Purpose: The goal of this study was to compare the times to onset of analgesia and the other analgesic efficacy of 75 mg tramadol/650 mg acetaminophen and 20 mg codeine/500 mg acetaminophen/400 mg ibuprofen in the treatment of acute pain after oral surgery. Patients and Methods: Using a randomized, single-dose, parallel-group, single-center, and active-controlled test design, this clinical study compared the times to onset of analgesia using a two-stopwatch technique and the other analgesic efficacy of the single-dose tramadol/acetaminophen and codeine/acetaminophen/ibuprofen. These were assessed in 128 healthy subjects with pain from oral surgical procedures involving extraction of one or more impacted third molars requiring bone removal. From the time of pain development, the times to onset of perceptible and meaningful pain relief, pain intensity, pain relief, an overall assessment, and adverse events of the study medications were recorded for 6 hours. Results: The demographic distribution and baseline pain data in the two groups were statistically similar. The median times to onset of perceptible pain relief were 21.0 and 24.4 minutes in the tramadol/acetaminophen and codeine/acetaminophen/ibuprofen groups respectively and those to onset of meaningful pain relief were 56.4 and 57.3 minutes, which were statistically similar. The other efficacy variables such as mean total pain relief (TOTPAR) and the sum of pain intensity differences (SPID) were also similar in the early period after pain development and drug dosing. The safety of tramadol/acetaminophen was well tolerated and very comparable to that of codeine/acetaminophen/ibuprofen. Conclusions: In this acute dental pain model, the onset of analgesia and analgesic efficacy of tramadol/acetaminophen was comparable to that of codeine/acetaminophen/ibuprofen. These results showed that tramadol/acetaminophen was recommendable for fast and effective treatment in the management of postoperative acute pain.

키워드

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