Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Traditional oriental herbal medicine, Jukyeoondam-tang, occludes aconitine-induced ventricular arrhythmia in hearts

  • Ha, Ki-Chan (Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk University) ;
  • Chae, Han-Jung (Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk University) ;
  • Piao, Cheng-Shi (Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk University) ;
  • Chae, Soo-Uk (Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk University) ;
  • Kim, Hyung-Ryong (Department of Dental Pharmacology and Nano-Science & Technology Research Institute, School of Dentistry) ;
  • Chae, Soo-Wan (Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk University)
  • Published : 2004.09.30
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Abstract

We showed the effects of the traditional herbal medicine, Jukyeoondam-tang (JO-T, Zhu-ru-Wen-Dan-Tang in Chinese), on ventricular arrhythmia induced by aconitine. Electrophysiological experiments with conventional microelectrode techniques revealed that JO-T potently suppressed the aconitine-induced arrhythmias in ventricular strips of the rat. In the aconitine-induced arrhythmia model of the rat, pretreatment with JO-T $(100\;{\mu}g/ml)$ completely occluded the appearance of ventricular tachyarrhythmia (VT) or ventricular fibrillation (VF) induced by aconitine. Furthermore, the aconitine-induced ventricular arrhythmia was occluded by $Na^+$ channel blocker quinidine but was not occluded by $K^+$ channel blocker glibenclamide $(3\;{\mu}mol/L)\;and\;Ca^{2+}$ channel blocker nifedipine $(10\;{\mu}mol/L)$. We also confirmed the effect of JO-T in the ischemia-reperfusion (I/R)-induced arrhythmia model of the rat. JO-T did not affect the I/R-induced arrhythmias in rats. JO-T may alleviate the risk of ventricular arrhythmias following aconitine. These results suggest that JO-T is a potent antiarrhythmic drug having a$Na^+$ channel-blocking action.

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