Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Gene Therapy Vectors: A Current Research Insight

유전자치료를 위한 벡터 개발의 연구 동향

  • Son, Eun-Hwa (Dept. of Pharmacognosy Material Development, Samcheok National University) ;
  • Sohn, Eun-Soo (Department of Information Analysis, Korea Institute of Science and Technology Information(KISTI)) ;
  • Pyo, Suhk-Neung (Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University)
  • 손은화 (삼척국립대학교 생약자원개발학과) ;
  • 손은수 (한국과학기술정보연구원(KISTI) 정보분석부) ;
  • 표석능 (성균관대학교 약학부)
  • Published : 2004.10.20
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Abstract

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.

Keywords

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