Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effects of Orostachys japonicus A. Berger on the Immune System

와송(瓦松) 추출물이 면역체계에 미치는 영향

  • Kwon, Jin (Dept. of Medical Administration, Kunjang College) ;
  • Han, Kwang-Soo (Dept. of Herb Resource, Woosuk University)
  • 권진 (군장대학 의무행정과) ;
  • 한광수 (우석대학교 허브자원학과)
  • Published : 2004.09.30
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Abstract

The purpose of this research was to investigate the effect of Orostachys japonicus A. Berger (OJB) on the immune system. Administration of OJB (500 mg/kg) enhanced viability of splenocytes and thymocytes in BALB/c mice, and also OJB increased of splenic T lymphocytes, significantly, increased CD4 positive $T_H$ cells and CD8 positive Tc cells. OJB markedly, enhanced the production of ${\gamma}-interferon$ in mice serum. OJB accelerated the apoptosis of L1210 and U937 leukemia cells and increased the expression of apoptosis-related ICE, c-myc, p53 gene. These results suggest that OJB have an immuno-regulatory and anti-cancer activity.

와송 (OJB)의 면역 및 항암 효과를 관찰한 결과, 와송은 생쥐의 비장 및 흉선세포의 생존율을 증가시켰으며, 임파구 아집단분석 결과 비장 T세포를 유의성있게 증가시켰는데 비장 T세포 중의 $T_H$세포 및 Tc세포가 모두 증가되었고, 혈청 중 ${\gamma}-interferon$의 생성을 현저하게 증가시켰다. 또한 와송은 L1210세포 및 U937세포 등의 백혈병세포의 아폽토시스를 촉진시키는 항암능력을 보유하고 있었다.

Keywords

References

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