Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antitumor Activity of Cordyceps militaris on Human Cancer Cell Line

큰 번데기 동충하초의 사람 암세포에서의 항암효과

  • Published : 2004.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Cordyceps militaris (CM) has been used as antidiabetics, anticancer, endocrine and sexual functions enhancement in the traditional medicine. Water soluble fractions of CM showed cytotoxic activities on the three kinds of human cancer cell lines, stomachic adenocarcinoma(SNU-1), colorectal adenocarcinoma (SNU-C4), and hepatocellular carcinoma(SNH-354). Cytotoxic activity guided isolation and identification of active fractions afforded cordycepin as an active component.

Keywords

References

  1. 성재모(1966) 한국의 동충하초 272-274, 교학사, 서울
  2. Zhu, J. S., Halpern, G. M, and Jones, K. (1998) The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis: part 1. J. Altern. Complement M. 4: 289-303 https://doi.org/10.1089/acm.1998.4.3-289
  3. Zhu, J. S., Halpern, G. M, and Jones, K. (1998) The Scientific Rediscovery of an Ancient Chinese Herbal Regimen: Cordyceps sinensis: part II. J. Altern. Complement M. 4: 2429-2457
  4. Bok, J. W., Lermer, L., Chilton, J., Klingeman, H. G., and Towers, G. H. (1990) Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 51: 891-898
  5. Kuo, Y C., Lin, C. Y, Tsai, W. J., Wu, C. L., Chen, C. F, and Shiao, M S. (1994) Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest. 12: 611-615 https://doi.org/10.3109/07357909409023046
  6. Kim, H. W., Kim, Y H., Cai, X. F, Nam, K. S., Lee, S. J., An, H. S., Jeung, E. H., Yun, S. H., Sung, S. K., Lee, S. J., and Hyun, J. W. (2001) In vitro Antitumor Activity of Ergosterol Peroxide Isolated from Cordyceps militaris on Cancer Cell Lines from Korean Patients. Kor. J. Mycol. 29: 61-66
  7. Kiho, T., Ookubo, K., Usui, S., Ukai, S., and Hirano, K. (1990) Structural featurws and hypoglycemic activity of a polysaccharide (CS-FlO) from the cultured mycellium of Cordyceps sinensis. BioI. Pharm. Bull. 22: 966-970
  8. Kino, T., Yamane, A., Hui, J., Usui, S., and Ukai (1996) S. Polysaccharides in fungi. XX. Hypoglycemic activity of a polysaccharide (CS-F30) from cultured mycellium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Bioi. Pharm. Bull. 19: 294-296 https://doi.org/10.1248/bpb.19.294
  9. Kwon, Y. M., Cho, S. M., Kim, J. H., and Lee, M W. (2001) Hypoglycemic Effect of Cordyceps militaris. Kor. J. Pharmmacogn. 32: 327-329
  10. Huang, B. M., Hsu, C. C., Tsai, S. J., Sheu, C. C., and Leu, S. F (2001) Effects of Cordyceps sinensis on testosterone production in normal Mouse Leydig cells. Life Sci. 19: 2593-2602
  11. Liu, J., Yang, X., Chen, Z., and Li, J. (1997) Anticarcinogenic effect and hormonal effect of Cordyceps militaris Link. Zhongguo Zhong Za Zhi. 22: 111-113
  12. Yang, L. Y, Chen, A., Kuo, Y C., and Lin, C. Y (1999) Efficacy of a pure compound HI-A extracted from Cordyceps sinensis on autoimmune disease of MRL 1pr/1pr mice. J. Lab. Clin. Med. 134: 492-500 https://doi.org/10.1016/S0022-2143(99)90171-3
  13. Yamaguchi, N., Yoshida, J., Ren, L. J., Chen, H., Miyazawa, Y, Fujii, Y, Hung, Y. X., Takamura, S., Suzuki, S., and Koshimura, S. (1990) Augmentation of various immune reactivities of tumor-bearing hosts with an extract of Cordyceps sinensis. Biotherapy. 2: 199-205 https://doi.org/10.1007/BF02173520
  14. Dai, G., Bao, T., Xu, c., Dooper, R., and Zhu, J. S. (2001) CordyMax Cs-4 improves steadystate bioenergy status in mouse liver. J. Altern. Complement Med. 7: 231-240 https://doi.org/10.1089/107555301300328106
  15. Cho, M A., Lee, D. S., Kim, M. J., Sung, J. M., and Ham, S. S. (2003)Antimutagenicity and Cytotoxicity of Cordycepin Isolated form Cordyceps militaris. Food Science and Biotechnology. 12: 472-475