국내산 오리나무속 식물로부터 Diarylheptanoid계열 화합물의 함량분석

Quantitative Determination of Diarylheptanoid Compounds from Korean Alnus

  • 발행 : 2004.12.30

초록

Genus Alnus are deciduous board-leaved trees or shrubs found in the damp place and mountain and more than 17 species are growing in Korea. The bark of Alnus japonica has been used for the treatment of fever, hemorrhage and diarrehea in oriental traditional medicine. Quantitative analysis of diarylheptanoids which were characteristic components of Alnus species (A. japonica, A. hirsuta, and A. hirsuta var. sibirica), has been conducted by HPLC. The results showed that these plants were rich source of diarylheptanoids and the amount of oregonin and hirsutanonol which were major diarylheptanoids showed seasonal variation.

키워드

참고문헌

  1. (1985) 中藥大辭典(3권), P3042(1985)小學館, 東京
  2. Lee, S. J. (1966) 40, Korean Folk Medicine, 서울
  3. Lee, M. W., Park, M. S., Jeong, D. W., Kim, K. H., Kim, H. H. and Toh, S. H. (2000) Diarylheptanoids from the leaves of Alnus hirsuta Turcz. Arch. Pharm. Res., 23: 50-53 https://doi.org/10.1007/BF02976466
  4. Jeong, D.W., Kim, J. S., Cho, S. M., Lee, Y. A., Kim, K. H., Kim, S. W. and Lww, M. W. (2000) Diarylheptanoids from the stem barks of Atnus hirsuta var. sibirica. Kor. J. Phamacog., 31: 28-33
  5. Lee, M. W., Jeong, D. W., Lee. Y. A., Park, M. S., Jeong, D. W. and Toh, S. H. (1999) Flavonoids from the leave of AInushirsuta. Yakhak Hoeji, 43: 547-552
  6. Ahn, K. W., Toh, S. H., Jeong, D. W., Kim, J.S., Cho, S. M.and Lee, M. W. (2000) Flavonoids from the leave of Alnusmaximowiczii Call. Yakhak Hoeji, 44: 41-46
  7. Lee, M, W., Tanaka, T, Nonaka, G. and Nishioka, I. (1992)Hirsunin, an ellagitannin with a diarylheptanoid moiety fromAlnus hirsuta var. microphylla. Phytochemistry, 31: 967-970
  8. Lee, M, W., Tanaka, T., Nonaka, G. I. and Nishioka, I. (1992) Dimenc ellagitannins from Alnus japonica. Phytochemistry, 31: 2835-2839 https://doi.org/10.1016/0031-9422(92)83642-C
  9. Cho, S. M., Kwon, Y. M., Lee, J. Yon, K. H. and Lee, M. W. (2002) Melanogenesis inhibitory activities of diarylhep-tanoids from AInus hirsuta Turcz in B16 mouse melanomacell. Arch. Pharm. Res., 25: 885-888 https://doi.org/10.1007/BF02977009
  10. Lee, M. W., Kim, J. H., Jeong, D. W., Ahn, K. H., Toh, S. H. and Surh, Y. J. (2000) Inhibitory of cyc1ooxygenase-2 expressione by diarylheptanoids from the bark of Alnus hirsuta var. sibirica. BioI. Pharm. Bull., 23: 517-518 https://doi.org/10.1248/bpb.23.517
  11. Lee, M. W, Kim, N. Y., Park, M. S., Ahn, K. H., Toh, S. H., Hahn, D. R., Kim, Y. C. and Chung, H. T. (2000) Dia-rylheptanoids with in vitro inducible nitinc oxide synthesis inhibitory activity from Alnus hirsuta. Planta. Med., 66: 551-553 https://doi.org/10.1016/0002-9343(79)91162-8
  12. Lee, Y. A., Jeong, D. W., Kim, K. H., Kim, J. S., Kim, S. W.and Lee, M. W.(2000) Antioxidant effect of diarylheptanoidsfrom Alnus hirsuta. Yakhak Hoeji, 47: 193-196
  13. Lee., J. H., Yeom, S. H., Kim, M. K., Kim, H. J., Shim, J. G. and Lee M. W. (2003) Antioxidative activity of diarylhep-tanoids from Atnus hirsuta and their structural relationship. Kor. J. Pharmacog. 34: 190-192