Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Water Extracts from Thesium chinense Tunczaninov and Prunella vulgaris L. on Aromatase and Cyclooxygenase Activities

하고초 열수추출물이 Aromatase와 Cyclooxygenase 활성에 미치는 영향

  • Nam, Kyung-Soo (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Shon, Yun-Hee (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
  • 남경수 (동국대학교 난치병한양방치료연구센터 및 의과대학 약리학교실) ;
  • 손윤희 (동국대학교 난치병한양방치료연구센터 및 의과대학 약리학교실)
  • Published : 2004.06.30
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Abstract

Water extracts from Thesium chinense Tunczaninov (TCTW) and Prunella vulgaris L. (PVW) were tested for aromatase and cyclooxygenase activities. TCTW and PVW were capable of suppressing aromatase in a human placenta microsomal assay. PVW was shown to be more effective than TCTW in the suppression of aromatase activity. TCTW significantly inhibited cyclooxygenase-2 (COX-2) activity at the concentration of 0.25 (p<0.05), 0.5 (p<0.01) and 2.5 mg/ml (p<0.005). PVW also inhibited COX-2 activity in a dose-dependent manner in a concentration range of $0.05{\sim}2.5\;mg/ml$. The expression of COX-2 was inhibitied by TCTW and PVW in western blot analysis. These results suggest that TCTW and PVW may have breast cancer chemopreventive potentials by inhibiting aromatase and cyclooxygenase activities.

Keywords

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