생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

자생식물 추출물의 세포 분산 활성

Cell Scattering Activity of Natural Plant Extracts

  • 조민경 (단국대학교 의과대학교 미생물학교실) ;
  • 김영재 (창원대학교 자연과학대학) ;
  • 신득용 (단국대학교 의과대학교 미생물학교실) ;
  • 최태생 (단국대학교 의과대학교 미생물학교실)
  • Cho, Min-Kyung (Department of microbiology, College of Medicine, Dankook University) ;
  • Kim, Young-Jae (Department of Microbiology, College of National Sciences, Changwon National University) ;
  • Shin, Deug-Y (Department of microbiology, College of Medicine, Dankook University) ;
  • Choi, Tae-Saeng (Department of microbiology, College of Medicine, Dankook University)
  • 발행 : 2004.03.30
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초록

Cell-scattering is a phenotypic change easily observed in most epithelial cells treated with Hepatocyte Growth Factor /scatter Factor (HGF/SF) or phorbol esters (PKC-activators). Recent studies have shown the possibilities to use as therapeutic materials of HGF/SF or non tumor promoting phorbol esters for liver disease, cancer and AIDS. In this study, we tested a cell-scattering activity of 534 methanol extracts from plants inhabiting in Korean peninsula using the phenotype-based assay system. Nine Active extracts were detected : Daphne genkwa, Daphne kiusiana, and Aleurites fordii showed high activity (+++), Euphorbia sieboldiana and Rhodotypos scandens showed medium activity (++), Sambucus sieboldiana var. pendula, Catalpa bignonioides, Sambucus sieboldiana and Lycoris squamigera showed low activity (+). Furthermore, the effects of these active materials in the culture cells were investigated with biochemical studies.

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