Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Quality Control and Evaluation of Platycodon grandiflorum: Implications for Future Management

  • Xu, Bao-Jun (The Pharmaceutical Institute, Dalian University) ;
  • Zheng, Yi-Nan (College of Chinese Material Medicine, Jilin Agricultural University) ;
  • Sung, Chang-Keun (Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University)
  • Published : 2004.08.31
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Abstract

Platycodi Radix, as one of the most important traditional oriental materia medica, is utilized frequently in clinical practice and dietary in China, Korea, and Japan. To evaluate definitely the quality of Platycodi Radix, and provide scientific data for commodity circulation, new product development and clinical application of Platycodi Radix, we summarized its medical history, application status, chemical compositions, bioactivities, cultivation, international circulation, quality evaluation, dosage and safety, and brought forward some constructive suggestions on further establishment of international criteria for quality control of Platycodon grandiflorum.

Keywords

References

  1. Akiyama, T, Tanaka, O., and Shibata, S., Chemical studies on the oriental plant drugs. XXX. Sapogenins of the roots of PIatycodon grandifIorum A. De Candolle (1) Isolation of the sapogenins and the stereochemistry of polygalacic acid. Chem. Pharm. Butt. 20(9), 1945-1951 (1972). https://doi.org/10.1248/cpb.20.1945
  2. Arai, I., Komatsu, Y, Hirai, Y, Shingu, K., ida, Y., Yamaum, H., Yamamoto, T., Kuroiwa, Y., Sasaki, K., and Taguchi, S., Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. Planta Med. 63(5), 419-424 (1997). https://doi.org/10.1055/s-2006-957725
  3. Bensky, D. and Gamble, A., Chinese Herbal Medicine: Materia Medica, rev. ed., Eastland Press, Seattle, WA (1993)
  4. Chang, H.M. and But, P.P.H., Pharmacology and Applications of Chinese Materia Medica. World Scientific Publishing, Singapore (1986)
  5. Chen, Y.H., The extract of inulin from PIatycodon gmndiforum. Journal of LanZhou Medical College 18(4), 253 (1992).
  6. Choi, C.Y., Kim, J.Y, Kim, Y.S., Chimg, Y.C., Seo, J.K., and Jeong, H.G., Aqueous extract isolated from PIatycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor-$\alpha$ from murine macrophages. int. Immuno-pharmacol. 1(6), 1141-1151 (2001a).
  7. Choi, C.Y., Kim, J.Y., Kim, Y.S., Chung, Y.C., Hahm, K.S., and, Jeong, H.G., Augmentation of macrophage functions by an aqueous extract isolated from PIatycodon grandiflorum. Cancer Lett. 166(1), 17-25 (2001b). https://doi.org/10.1016/S0304-3835(01)00440-2
  8. Choi, S.S., Han, E.J., Lee, T.H., Lee, J.K., Han, K.J., Lee, H.K., and Suh, H.W., Antinociceplive mechanisms of platycodin D administered intracerebroventricularly in the mouse. PIanta Med. 68, 794-798 (2002). https://doi.org/10.1055/s-2002-34396
  9. Chung, J.H., Shin, P.G., Ryu, J.C., Jang, D.S., and Cho, S.H., Pharmaceutical substances of PIatycodon grandiflorum (jacquin) A.De Candolle. Agric. Chem. Biotechml. 40(2), 152-156 (1997).
  10. Dong, Z.L. and Yu, S.F., Modem Study and Apptication ofMateria Medica. China Ocean Press, Beijing (1990)
  11. Elyakov, G.B., Chemical studies on platycodoside C, a new glycoside from Ptatycodon grandiflorum (jacg.) A.De. Tetrahedron Lett. 35, 3651-3652 (1972)
  12. Han, L.K., Xu, B.J., Kimura, Y., Zheng, Y.N., and Okuda, H., Platycodi Radix affects lipid metabolism in mice with high fat dietinduced obesity. J. Nutr. 130, 2760-2764 (2000)
  13. Han, L.K., Zheng, Y.N., Xu, B.J., Okuda, H., and Kimura, Y, Saponins from Platycodi Radix ameliorate high fat diet-induced obesity in mice. J. Nutr. 132(8), 2241-2245 (2002)
  14. Han, S.B., Park, S. H., Lee, K. H., Lee, C.W, Lee, S.H., Kim, H.C., Kim, Y.S., Lee, H.S., and Kim, H.M., Polysaccharide isolated from the radix of Ptatycodon grandiflorum selectively activates B cells and macrophages but not T cells, int. Immunopharmacol. 1(11), 1969-1978 (2001) https://doi.org/10.1016/S1567-5769(01)00124-2
  15. Higashi, A., Arimoto, K., Iwata, Y, Ujita, K., Kawai, T., Kobayashi, Y, Sakorai, K., Shimada, Y, Takagi, A., Taniyama, T., Nakajima, K., Hisata, Y, Hosoda, K., Yamamoto, K., Yamamoto, Y., and Noguchi, M., Studies on the effect of preparation method of platycodon root on its quality. NaturaI Medicines 51(1), 56-62 (1997)
  16. Hosoda, K., Noguchi, M., Tomonari, K., and Nishijima, A., Studies on the cultivation and preparation of Platycodon root III. Effect of picking flower and fruit on the quality of skin peeled root. Chem. Pharm. BulI. 40(7), 1946-1947(1992) https://doi.org/10.1248/cpb.40.1946
  17. Huang, B.S. and Wang, YX., Thousand Formulas and Thousand Herbs of Traditional Chinese Medicine, Heilongjiang Education Piess, Harbin (1993)
  18. Inada, A., Murata, H., Somekawa, M., and Nakanishi, T., Phytochemical Studies of Seed of Medicinal Plants, II. A new dihydroflavonol glycoside and a new 3-methyl-1-butanol glycoside from seeds Platycodon grandiflorum ADe Candolle. Chem. Pharm. Butt. 40(11), 3081-3083 (1992) https://doi.org/10.1248/cpb.40.3081
  19. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y, Structuies of prosapogenins from roots of Platycodon grandiflorum, determined by carbon-13 and hydrogen-1 nuclear magnetic resonance spectroscopy. Chem. Pharm. Butt. 26(2), 671-673 (1978a) https://doi.org/10.1248/cpb.26.671
  20. Ishii, H., Tori, K., Tozyo, T., and Yoshimura, Y., Structures of polygalacin-D and $-D_{2}$ Platycodin-D and $-D_{2}$, and their monoacetaes, saponins isolated from Platycodon grandiflorum, detemiined by $^{13}C-NMR$ spectroscopy. Chem. Pharm. Butt. 26(2), 674-677 (1978b) https://doi.org/10.1248/cpb.26.674
  21. Ishii, H., Tori, K., Tozyo, T, and Yoshimura, Y., Structures of platycodin$-D_{3}$, Platycodinic-A, and their derivtives, saponins isolated from root of Platycodon grabdiflorum A. De deteimined by $^{13}C-NMR $ spectioscopy. Chem. Lett. 719-722 (1978c)
  22. Ishii, H., Kitagawa, L, Matsushita, K., Shirakawa, K., Tori, K., Tozyo, T., and Yoshimura, Y. Tetrahedron Left. 22, 1529-1532 (1981a) https://doi.org/10.1016/S0040-4039(01)90369-7
  23. Ishii, H., Matsushita, K., Shirakawa, K., Tozyo, T., and Yoshimura, Y, Saponins from roots of Platycodon grandiflorum. Part 1. Structure of prosapogenins. J. Chem. Soc. Perkin Trans. I. 1928-1933 (1981b) https://doi.org/10.1039/p19810001928
  24. Ishii, H., Tori, K., Tozyo, T., and Yoshimuia, Y, Saponins from roots of Platycodon grandiflorum. Part 2. Isolation and structure of new triterpene glycosides. J. Chem. Soc. Perkin Trans. I. 661-668 (1984) https://doi.org/10.1039/p19840000661
  25. Kim, G.S., Kim, H.T., Seong, J.D., Park, H.S, and Kim, S.D, Quantitative analysis of platycodin D from Platycodon grandiflorum by HPLC-ELSD. Korean J. Medicinal Cmp Sci. 10(3), 200-205 (2002)
  26. Kim, K.S., Ezaki, O., Ikemoto, S., and Itakura, H., Effects of Ptatycodon grandifIorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J. Nutr. Sci. Vitaminol. 41(4), 485-491 (1995a) https://doi.org/10.3177/jnsv.41.485
  27. Kim, K.S., Ezaki, O., and Ikemoto, S., Effects of platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. Yakugaku Zasshi 41, 485-491 (1995b)
  28. Kim, K.S., Seo, E.K., Lee, Y.C., Lee, T.K., Cho, Y.W., Ezaki, O., and Kim, C.H., Effect of dietary PIatycodon gmndiflorum on the improvement of insulin resistance in obese Zucker rats. J. Nutr. Biochem. 11(9), 420-424 (2000) https://doi.org/10.1016/S0955-2863(00)00098-X
  29. Kim, TJ., Lee, S.I., Lee, T.H., and Ko, J.S., isolation and determination of platycodin D from Platycodi radix. Analytical Sci. & TechnoI. 3(3), 399-404 (1990)
  30. Kim, Y.P., Lee, E.B., Kim, S.Y, Li, D.W., Ban, H.S., Lim, S.S., Shin, K.Y., and Ohuchi, K., Inhibition of prostaglandin $E_{2}$ production by platycodin D isolated from the root of Platycodon grandiforum. Planra Med. 67, 362-364 (2001) https://doi.org/10.1055/s-2001-14317
  31. Konishi, T, Tada, A., Shqji, J., Kasai, R., and Tanaka, O., The structures of platycodin A and C, monoacetycated saponins of the roots of PIatycodin grandiflorum. Chem. Pharm. Bull 26(2), 668-670 (1978) https://doi.org/10.1248/cpb.26.668
  32. Kubo, M., Nagao, T., Matsuda, H., and Namba, K., immune pharmacological studies on Ptatycodi radix (I): effect on the phagocytosis in mouse. Shoyakugaku Zasshi 40, 367-374 (1986)
  33. Kubota, T, Kitatani, H., and Hinoh, H., The structure ofplatycodigenic acid A, B, and C, Further triterpenoidconstituents of PIatycodon grandiflorom A. De Candolle.Chem. Comm. 22, 1313-1314 (1969)
  34. Lee, E.B., Pharmacological studies on PIatycodon grandiflorumA. DC. IV. A comparison of experimental pharmacologicaleffects of crude platycodin with clinical indications ofplatycodi radix (author's transl). Yahtgaku Zasshi 93(9), 1188-1194(1973) https://doi.org/10.1248/yakushi1947.93.9_1188
  35. Lee, E.B., Pharmacological studies on Platycodi radix. Kor. J. Pharmacog. 5(1), 49-60 (1974)
  36. Lee, E.B., Pharmacological activities of crude platycodin. J. Pharm. Soc. Korea 19, 164-176 (1975)
  37. Lee, K.J., and Jeong, H.G., Protective effect of Ptatycodi rodix on carbon tetrachloride-induced hepatotoxicity. Food Chem. Toxicol. 40(4), 517-525 (2002) https://doi.org/10.1016/S0278-6915(01)00104-1
  38. Lee, K.J., You, H.J., Park, S.J., Kim, Y.S., Chung, Y.C., Jeong, T.C. and Jeong H.G., Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett. 174(1), 73-81 (2001) https://doi.org/10.1016/S0304-3835(01)00678-4
  39. Lee, S.H., Patent on the method of cultivating the perennial balloonflower, Patent No. 045971, Korea (1991)
  40. Long, Q.Q., Total saponin contents of the root of wild and cultivated Platycodon grandiflorum. Zhong Yao Cai 12(3), 37-38 (1989)
  41. Nagao, T., Matsuda, H., Namba, K., and Kubo, M., Immune pharmacological studies on Platycodi radix (Ⅱ): anti-tumor activity of inulin from Platycodi radix. Shoyakugaku Zasshi 40, 375-380 (1986)
  42. Nikaido, T., Koike, K., Mitsunaga, K., and Saeki, T., Triterpenoid saponins from root of Platycodon grandiflorum. Natural Medicines 52(1), 54-59 (1998)
  43. Nikaido, T., Koike, K., Mitsunaga, K., and Saeki, T., Two new thterpenoid saponins from Platycodon grandiflorum. Chem. Pharm. Bull. 47(6), 903-904 (1999) https://doi.org/10.1248/cpb.47.903
  44. Oka, M., Ota, N., Mino, Y, Iwashita, T., and Komura, H., Studies on the conformational aspects of inulin oligomers. Chem. Pharm. Bull. 40(5), 1203-1207 (1992) https://doi.org/10.1248/cpb.40.1203
  45. Perry, L., Medicinal Plants of East and Southeast Asia. MIT Press, Cambridge, MA, USA. (1980)
  46. Pharmacopoeia Commission of PRC, Pharmacopoeia of the People's Republic of China, People's Medical Publishing House, Beijing (1988, 1995, 2000)
  47. Piao, H.S., Kang, C.H., Kim, H.C., and Ahn, D.K., A study of standardization of Platycodon erandiflorum A.DC., Campanu-laceae with platycodin D. J. of Oriental Medicinwe 3(1), 125-130 (1998)
  48. Saeki, T., Koike, K., and Nikaido, T, A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis. Ptanta Med. 65(5), 428-431 (1999) https://doi.org/10.1055/s-1999-14021
  49. Saeki, T, and Nikaido, T., Evaluations of saponin properties of HPLC analysis of Platycodon grandiflorum A.DC. Yakueaku Zasshi 123(6), 431-441 (2003) https://doi.org/10.1248/yakushi.123.431
  50. Shin, C.Y., Lee, W.J., Lee, E.B., Choi, E.Y., and Ko, K.H., Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. Planta Med. 68, 221-225 (2002) https://doi.org/10.1055/s-2002-23130
  51. Shon, M.Y., Seo, J.K., Kim, H.J., and Sung, N.J., Antimutagenic effect of extract of Platycodon grandiflorum. Korean J. Food Sci. Technol. 33(6), 651-655 (2001)
  52. Tada, A., Kaneiwa, Y, Shoji, J., and Shibata, S., Studies on the saponins from roots of Platycodon grandialorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem. Pharm. Bull. 23 (11), 2965-2972 (1975) https://doi.org/10.1248/cpb.23.2965
  53. Takagi, K., and Lee, E.B., Pharmacological studies on Platycodon arandiflorum A. DC. I. Acute toxicity and central depressant activity of crude platycodin. Yakugaku Zasshi 92(8), 951-960(1972a) https://doi.org/10.1248/yakushi1947.92.8_951
  54. Takagi, K., and Lee, E.B., Pharmacological studies on Platycodon grandiflorum A. DC. II. Anti-inflammatory activity of crude platycodin, its activities on isolated organs and other pharmacological activities. Yakugaku Zasshi 92(8), 961-968(1972b)
  55. Takagi, K., and Lee, E.B., Pharmacological studies on Platycodon grandiflorwn A. DC. III. Activities of crude platycodin on respiratory and circulatory systems and its other Pharma-cological activities. Yakugaku Zasshi 92(8), 969-973 (1972c) https://doi.org/10.1248/yakushi1947.92.8_969
  56. WHO, WHO monogrphs on selected medicinal plants: Radix Platycodi. Volume 1, WHO Geneva. p. 213-220 (1999)
  57. Xu, B.J., Zheng, Y.N. Cui, M., and Song, F.R., Identification of platycodin-D by electrospray mass spectrum. Chinese Journal of Medicinal Chemistry 10(3), 193-196 (2000)
  58. Xu B.J. Xu, C.L., Cui, M., Liu, M.X., and Zheng, Y.N., Identifi-cation on saponins composition of Platycodon grandiflorum applied mass spectral analyses method. Journal of Jilin Agricultural University 21(1), 35-41 (1999)
  59. Xu, C.L., Zheng, Y.N., Yang, L.H., Liu, M.X., and Xu, B.J., HPLC determination of platycodin D in different pans of Platycodon grandiflorum harvested at different time. Journal of Jilin Agricultural University 23(1), 58-60, 64 (2001)
  60. Xu, C.L., Yang, L.H., Zheng, Y.N., Liu, M.X., and Xu, B.J., determination of platycodin D of Radix Platycodi in different places by RP-HPLC. Journal of Jilin Agricultural University 21(4), 35-38 (1999)
  61. Yoon, Y. D., Han, S.B., Kang, J. S., Lee, C. W., Park, S.K., Lee, H.S., Kang, J.S., and Kim, H. M., Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum. Int. Immunopharmacol. 3, 1873-1882 (2003) https://doi.org/10.1016/j.intimp.2003.09.005
  62. Zhang, X.Y., A preliminary study on the expectorant action of Rheum plamatum and its mechanism of action. Liangning Journal of Traditional Chinese Medicine 11(9), 44-46 (1987)
  63. Zhou, R.H., Chinese medicine resource. Chinese medicine science and technology publishing House, Beijing, 486-489(1994)