Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Lignans from the Fruits of Schizandra chinensis and Their Inhibitory Effects on Dopamine Content in PC12 Cells

  • Seo, Seon-Mi (Department of Forest Resources and Environmental Science, Korea University) ;
  • Lee, Hak-Ju (Div. Wood Chemistry and Microbiology, Korea Forest Research Institute) ;
  • Park, Young-Ki (Div. Biotechnology, Korea Forest Research Institute) ;
  • Lee, Myung-Koo (College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Park, Jae-In (School of Forest Resources, Chungbuk National University) ;
  • Paik, Ki-Hyon (Department of Forest Resources and Environmental Science, Korea University)
  • Published : 2004.06.30
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Abstract

Five lignans including gomisin N (1), wuweizisu C (2), gomisin L1 (3), (+)-deoxyschizandrin (4), and gomisin J (5) have been isolated from the fruits of Schizandra chinensis. The structures of the isolated compounds were elucidated by analyzing MS and NMR spectra. Effects of the compounds isolated in this study on the dopamine content in PC12 cells were investigated to evaluate their inhibitory effectiveness. The gomisin N, wuweizisu C, and gomisin J showed 25.4%, 39.8%, and 35.1 %, respectively, inhibition effect on dopamine content in PC12 cells at the concentration of $50\;{\mu}g/ml$.

Keywords

References

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