Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지

The Effects of KongJin-Dan(KJD) on the Alzheimer's Disease Model Induced by CT105

공진단(拱辰丹)이 CT105로 유도된 Alzheimer's disease 병태(病態)모델에 미치는 영향

  • Chung, Dae-Kyoo (Department of Neuropsychiatry, College of Oriental Medicine, Daegu Haany University) ;
  • Hwang, Seon-Mi (Department of Neuropsychiatry, College of Oriental Medicine, Daegu Haany University)
  • 정대규 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 황선미 (대구한의대학교 한의과대학 신경정신과 교실)
  • Published : 2004.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This experiment was designed to investigate the effect of KongJin-dan(KJD) on the Alzheimer's disease. Method : The effects of KJD on $LI-1{\beta}$, IL-6, $TNF-{\alpha}$, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 and THP-1 cell treated by CT105 and AChE activity, APP production of PC-12 cell lysate treated by CT105 were investigated, respectively. Results : 1. KJD suppressed $LI-1{\beta}$, IL-6, $TNF-{\alpha}$, APP, AChE, GFAP mRNA in THP-1 and PC-12 cell treated by CT105. 2. KJD suppressed AChE activity and production of APP significantly in cell lysate of PC-12 cell treated by CT105. Conclusions : This study shows that KJD might be usefully applied for prevention and treatment of Alzheimer's disease.

Keywords