The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Regulatory Effect of Atopic Allergic Reaction by Chungsangbangpoong-Tang

청상방풍탕(淸上防風湯)의 아토피성 알레르기 반응(反應) 조절(調節) 효과(效果)

  • Lim, Tae-Hyung (College of Oriental Medicine, Wonkwang University) ;
  • Park, Eun-Jung (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University) ;
  • Lee, Hai-Ja (Department of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Han, Kyeung-Hoon (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University) ;
  • Na, Won-Kyeung (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University) ;
  • Jin, Kyong-Son (Department of Pediatrics, College of Oriental Medicine, Wonkwang University)
  • 임태형 (원광대학교 한의과대학) ;
  • 박은정 (원광대학교 전주한방병원 소아과) ;
  • 이해자 (원광대학교 한의과대학 소아과학교실) ;
  • 한경훈 (원광대학교 전주한방병원 소아과) ;
  • 나원경 (원광대학교 전주한방병원 소아과) ;
  • 진경선 (원광대학교 한의과대학 소아과학교실)
  • Published : 2004.12.31
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Abstract

Objective : To demonstrate of regulatory effect of atopic allergic regulation by Chungsangbangpoong-Tang(CBT), This experiment was studied. Methods : The author investigated a possible effect of CBT on cytokines production using human T cell line (MOLT-4) or human mast cell line (HMC-1). In addition, the author investigated whether CBT has inhitory effects on compound 48/80- induced histamine release from rat peritoneal mast cells (RPMC) and compound 48/80-induced ear swelling in ICR mice. Results : CBT (0.01 mg/ml)-containing medium in stimulated culture supernatants significantly increased IL-2 secretion compared with untreated MOLT-4, whereas CBT (0.01-1.0 mg/ml)-containing medium in stimulated culture supernatants significantly decreased IL-4 secretion compared with untreated MOLT-4. Significant reduced levels of IL -6 and $TNF-{\alpha}$ were observed in the HMC-l with CBT (P<0.05). CBT did not inhibit the histamine release from the RPMC but inhibit ear swelling response. Conclusion : These results suggest that CBT contributes to the treatment of atopic allergic reactions, such as atopic dermatitis and that its action may be due to regulation of cytokine production.

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