The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Regulatory Effects of Allergic Bronchial Asthma Responses by KagamJwaGwiEum

가감좌귀음(加減左歸飮)의 알레르기성 기관지천식(氣管支喘息) 반응(反應) 조절(調節) 효과(效果)

  • Park, Eun-Jung (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University) ;
  • Lee, Hai-Ja (Department of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Park, Jong-Ik (Department of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Park, Young-Joo (Department of Pediatrics, College of Oriental Medicine, Wonkwang University)
  • 박은정 (원광대학교 전주한방병원 소아과) ;
  • 이해자 (원광대학교 한의과대학 소아과학교실) ;
  • 박종익 (원광대학교 한의과대학 소아과학교실) ;
  • 박영주 (원광대학교 한의과대학 소아과학교실)
  • Published : 2004.12.31
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Abstract

Objective : KagamJwagwiEum(KJE) has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in Korea. To investigate the biological effect of KJE, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. Methods: HMC-1 was stimulated with phorbol 12-myristate 13-acetate(PMA) and calcium ionophore A23187. KJE by itself had no effect on viability of HMC-l. The effects of KJE on the secretion of tumor necrosis $factor-alpha(TNF-{\alpha})$, interleukin(IL)-6 and IL-8 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Results : KJE inhibited PMA plus A23187-induced $TNF-{\alpha}$ and IL-6 secretion. But KJE had no effect IL-8 secretion: KJE had immunoregulatory effects on cytokines, increased secretion of NO and $TNF-{\alpha}$ but did not effect IL-12 secretion when the cells were primed and trigged with $IFN-{\gamma}$ in the peritoneal macrophages of C57BL/6 mice. Conclusions : Taken together, these results suggest that KJE inhibit the production of inflammatory cytokines in HMC-1 cells and activate macrophages.

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