Journal of Korean Medicine for Obesity Research (한방비만학회지)
- Volume 4 Issue 1
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- Pages.139-160
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- 2004
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- 1976-9334(pISSN)
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- 2288-1522(eISSN)
A literature Review of Single Nucleotide Polymorphisms in Obesity Genes
비만 유전자 단일 염기 다형성 문헌 고찰
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Kim, Sung-Soo
(Department of Oriental Rehabilitation Medicine, college of Oriental Medicine, Kyung-hee University) ;
- Song, Hee-Ok (Department of Oriental Rehabilitation Medicine, college of Oriental Medicine, Kyung-hee University)
- Published : 2004.12.03
Abstract
The obesity is detrimental to the health of people living in affluent societies. Individual differences in energy metabolism are caused primarily by single nucleotide polymorphisms(SNPs), some of which promote the development of obesity-related type 2 diabetes mellitus. Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several different genes and environmental factors. In this review, five major conclusions are reached: (1)To be clinically significant, SNPs must be relevant, prevalent, modifiable, and measurable. (2)Differences in SNPs may have been caused by famine, ultraviolet light, alcohol, climate, agricultural revolution. livestock, lactase persistence, and westernized lifestyle. (3)Candidate obesity genes of calorie intake restriction are SIM 1, MC3R, MC4R, AGRP, CART, CCK, CNTFR, DRD2, Ghrelin, 5-HT receptor, NPY, PON and those of energy metabolism are LEP, LEPR, UCP1, UCP2, UCP3, B2AR, B3AR, PGC-1, Androgen receptor and those of fat mobilization are AGT, ACE, ADA, APM1, Apolipoproteins, PPAR, FABP, FOXC2, GCGR,