The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Inhibitory Effects of Liriopis Tuber on the Bleomycin-induced lung fibrosis in C57BL/6J mice

맥문동(麥門冬)이 C57BL/6J 생쥐의 Bleomycin 폐섬유화(肺纖維化)에 미치는 영향(影響)

  • Rhee, Hyung-Koo (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jung, Sung-Ki (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jung, Hee-Jae (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Byeong-Sam (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
  • 이형구 (경희대학교 한의과대학 폐계내과교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과교실) ;
  • 정희재 (경희대학교 한의과대학 폐계내과교실) ;
  • 이병삼 (경희대학교 한의과대학 폐계내과교실)
  • Published : 2004.12.30
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Abstract

Objectives : The aim was to identify the inhibitory effects of Liriopis Tuber on bleomycin-induced lung fibrosis by analysing the changes of imflammatory cell cytokines and SHI(Semiquantitative Histological Index), Materials and Methods : In this study fibrosis prone C57BL/6J mice were used. Control group was treated with blomycin(0.06mg/0.1 ml) by IT(intratracheal) instillation which is a popular method of inducing lung fibrosis and sample group took Liriopis Tuber water extract(38.0mg/10g body weight) orally for 14 days after IT instillation of blomycin. We measured the total and differential count of WBC, $IFN-{\gamma}$ & IL-4 in mice BALF and SHI(Semiquantitative Histological Index) from lung tissues of mice. BALF and lung tissues of mice were taken 14 days after IT instillation of blomycin. Results : In sample group total WBC count, proportion of neutrophil, SHI and IL-4 significantly(p<0.05) decreased, proportion of macrophage significantly(p<0.05) increased and proportion of lymphocyte, $IFN-{\gamma}$ did not decrease significantly. Conclusions : This study suggests that Liriopis Tuber has an inhibitory effects of pulmonary fibrosis by attenuation of inflammation and Th2 immune response. To determine whether this herbal medicine contribute to cure and prophylaxis of pulmonary fibrosis, further studies on the role of $IFN-{\gamma}$ relating to fibrosis are required.

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