Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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The Inhibitory Effect of Prunioside A Acyl Derivatives on NO Production in RAW 264.7 Cell

  • Lee, Woo-Yiel (Department of Bionanochemistry and Basic Sciences Research Institute, Workwang University) ;
  • Kim, Byung-Hee (Department of Bionanochemistry and Basic Sciences Research Institute, Workwang University) ;
  • Lee, Young-Hang (Department of Bionanochemistry and Basic Sciences Research Institute, Workwang University) ;
  • Choi, Han-Gil (Department of Biological Science, Wonkwang University) ;
  • Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Jang, Seon-Il (Department of Skin & Beauty, Seojeong College) ;
  • Kim, Young-Jun (Department of Immunology, Institute of Immtec Korea) ;
  • Chung, Hun-Taeg (Medicinal Resources Research Center of Wonkwang University) ;
  • Kim, Young-Soon (Department of Bionanochemistry and Basic Sciences Research Institute, Workwang University) ;
  • Chai, Kyu-Yun (Department of Bionanochemistry and Basic Sciences Research Institute, Workwang University)
  • Published : 2004.10.20
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Abstract

Prunioside A is a unique, highly oxidized monoterpene glycoside isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora's root. The ester derivatives were synthesized from the hydrolyzed compounds of prunioside A by ${\beta}$-glucosidase. The derivatives showed suppressive effects on the generation of nitric oxide in murine machrophage-like RAW 264.7 cells stimulated by lipopolysaccharide and interferon- ${\gamma}$.

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