Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Biological Activities of Methyl-4-[[(2E)-3,7-dimethyl-oxy]-3-hydroxybenzoate

  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University) ;
  • Oh, Hyun-Ju (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University) ;
  • Lim, Jin-A (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University) ;
  • Chun, Hyun-Ja (Division of natural Sciences, Wonkwang University) ;
  • Lee, Hyun-Ok (Department of Dental Hygiene, Wonkwang Health Science College) ;
  • Ahn, Jong-Woong (Division of Ocean Science, College of Ocean Science and Technology, Korea Maritime University) ;
  • Perry, Nigel B. (Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Ltd, Department of Chemistry, Otago University) ;
  • Kim, Hyung-Min (Department of Pharmacology, School of Oriental Medicine, Kyung Hee University)
  • Published : 2004.02.20
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Abstract

Methyl-4-[[(2E)-3,7-dimethyl-2,6-octadienyl]oxy]-3-hydroxybenzoate (5) has been identified from the New Zealand liverwort Trichocolea hatcheri (T. hatcheri) on the basis of spectroscopic evidence. This compound was tested for its growth inhibitory effects against tumor cell lines, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. It showed growth inhibition activity against Staphylococcus epidermidis (MIC, 1,000 ${\mu}$g/mL). These results suggest that compound 5 possesses antitumoral , antimicrobial and antioxidative activities.

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References

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