대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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갈화(葛花)의 항돌연변이(抗突然變異) 활성(活性)에 관한 연구(硏究)

A Study on Antimutagenic acitivities of from Puerariae Flos Extracts

  • 정영재 (동국대학교 한의과대학 내과학교실) ;
  • 김미랑 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실)
  • Jeong Young-Jae (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim Mi-Rang (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Seo Woon-Gyo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2004.12.01
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초록

Antigenotoxicity test (SOS chromotest), antimutagenecity test (Ames test), and antioxidant test (NBT method and xanthine-xanthine oxidase method) were carried out using water-soluble and methanolic extracts from Puerariae Flos. Against the mutagens MNNG and NQO, antigenotoxic activity of methanolic extracts were much more effective than that of water-soluble ones. When the methanolic extract was added to the certain concentration $(100{\mu}{\ell}/tube)$, antigenotoxic acivity against the mutagen MNNG was enhanced. Contrary to the water-soluble extract, the methanolic extract showed high antigenotoxicity against the mutagen NQO with increment of the extract. Against the mutagen MNNG with Ames test, antimutagenic activity of the methanolic extract at $300{\mu}{\ell}/tube$ was 96% as an inhibition ratio of revertant forming CFU/plate. The antioxidant activity of water-soluble extract was comparatively higher than that of the methanolic one.

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