The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 25 Issue 1
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- Pages.46-58
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- 2004
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- 1226-9174(pISSN)
The effect of Injinchunggan-tang(Yinchenqinggan-tang) on Inflammatory Cytokine Gene Expression in Kupffer Cells
인진청간탕(茵蔯淸肝湯)이 kupffer cell 의 inflammatory cytokine 발현에 미치는 영향
- Kim Ji-Kwon (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Kim Young-Chul (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Lee Jang-Hoon (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Woo Hong-Jung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
- 김지권 (경희대학교 한의과대학 간계내과학교실) ;
- 김영철 (경희대학교 한의과대학 간계내과학교실) ;
- 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
- 우홍정 (경희대학교 한의과대학 간계내과학교실)
- Published : 2004.12.01
Abstract
Objectives : This study was designed to investigate the effects of Injinchunggan-tang(Yinchenqinggan-tang) on the expression of inflammatory cytokine genes and proteins in kupffer cells. Materials and Methods : The mRNA expression level and protein secretion level were measured using quantitative RT-PCR and ELISA assay respectively in Injinchunggan-tang-treated and untreated kupffer cells after exposed to ethanol, acetaldehyde and lipopolysaccharide. Results : Injinchunggan-tang(Yinchenqinggan-tang) reduced mRNA expression level and protein secretion level of